Four spatial points that define enzyme families

被引：13

作者：

Ivan, Gabor ^{[1
,2
]}

Zoltan Szabadka ^{[1
,2
]}

Ordog, Rafael ^{[1
,2
]}

Vince Grolmusz ^{[1
,2
]}

Gabor Naray-Szabo ^{[3
,4
]}

机构：

[1] Eotvos Lorand Univ, Prot Informat Technol Grp, H-1117 Budapest, Hungary

[2] Uratim Ltd, H-4400 Nyiregyhaza, Hungary

[3] Eotvos Lorand Univ, Lab Struct Chem & Biol, H-1117 Budapest, Hungary

[4] Eotvos Lorand Univ, Prot Modeling Grp, H-1117 Budapest, Hungary

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 04期

关键词：

Catalytic triad; Data mining; Protein Data Bank; PATTERNS;

D O I：

10.1016/j.bbrc.2009.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads. We found that solely the geometric properties of just four points in the spatial structure of these enzymes are characteristic to their family (Fig. 3). (C) 2009 Elsevier Inc. All rights reserved

引用

页码：417 / 420

页数：4

共 8 条

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