Chemopreventive effects of sandalwood oil on skin papillomas in mice

被引：33

作者：

Dwivedi, C

AbuGhazaleh, A

机构：

[1] College of Pharmacy, Box 2202C, South Dakota State University, Brookings

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 1997年 / 6卷 / 04期

关键词：

chemoprevention; ornithine decarboxylase activity; sandalwood oil; skin papillomas;

D O I：

10.1097/00008469-199708000-00013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The essential oil, emulsion or paste of sandalwood (Santalum album L) has been used in India as an ayurvedic medicinal agent for the treatment of inflammatory and eruptive skin diseases, In this investigation, the chemopreventive effects of sandalwood oil (5% in acetone, w/v) on 7,12-dimethylbenz(a)anthracene-(DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted skin papillomas, and TPA-induced ornithine decarboxylase(ODC) activity in CD1 mice were studied, Sandalwood oil treatment significantly decreased papilloma incidence by 67%, multiplicity by 96%, and TPA-induced ODC activity by 70%. This oil could be an effective chemopreventive agent against skin cancer.

引用

页码：399 / 401

页数：3

共 4 条

[1]

[Anonymous], HDB AYURVEDIC MED PL

[2]

CHOPRA RN, 1969, S GLOSSARY INDIAN ME

[3] MODULATION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY BY CALCIUM AND VERAPAMIL IN MOUSE [J].