The Potential Mechanisms of the Neuroprotective Actions of Oil Palm Phenolics: Implications for Neurodegenerative Diseases

被引:8
作者
Ibrahim, Nurul 'Izzah [1 ]
Muhammad Ismail Tadj, Nur Balqis [1 ]
Rahman Sarker, Md. Moklesur [2 ]
Naina Mohamed, Isa [1 ]
机构
[1] Univ Kebangsaan Malaysia, Pharmacoepidemiol & Drug Safety Unit, Dept Pharmacol, Fac Med,Med Ctr, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
[2] State Univ Bangladesh, Dept Pharm, 77 Satmasjid Rd, Dhaka 1205, Bangladesh
关键词
oil palm phenolics; oxidative stress; antioxidant; anti-inflammatory; neuroprotection; OXIDATIVE STRESS; FREE-RADICALS; PROTOCATECHUIC ACID; NEUROTROPHIC FACTOR; CATECHOLAMINE SENSITIVITY; 4-HYDROXYBENZOIC ACID; LIPID-PEROXIDATION; HEME OXYGENASE-1; APOLIPOPROTEIN-E; OLIVE OIL;
D O I
10.3390/molecules25215159
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurodegenerative diseases (ND) can be characterized by degradation and subsequent loss of neurons. ND has been identified as the leading cause of disability-adjusted life years (DALYs) worldwide and is associated with various risk factors such as ageing, certain genetic polymorphisms, inflammation, immune and metabolic conditions that may induce elevated reactive oxygen species (ROS) release and subsequent oxidative stress. Presently, no specific cure or prevention is available for ND patients; the symptoms can be only alleviated via drug treatment or surgery. The existing pharmacological treatments are only available for partial treatment of the symptoms. A natural product known as oil palm phenolics (OPP), which is high in antioxidant, could become a potential supplementary antioxidant for neurodegenerative health. OPP is a water-soluble extract from palm fruit that demonstrated medicinal properties including anti-tumor, anti-diabetic and neuroprotective effects. In this review, OPP was proposed for its neuroprotective effects via several mechanisms including antioxidant and anti-inflammatory properties. Besides, OPP has been found to modulate the genes involved in neurotrophic activity. The evidence and proposed mechanism of OPP on the neuroprotective health may provide a comprehensive natural medicine approach to alleviate the symptoms of neurodegenerative diseases.
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页数:20
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