Simple and facile electrocatalytic approach to medicinally relevant spirocyclopropylpyrazolones directly from pyrazoline-5-ones and activated olefins

被引：21

作者：

Elinson, Michail N. ^{[1
]}

Dorofeeva, Evgeniya O. ^{[1
]}

Vereshchagin, Anatoly N. ^{[1
]}

Korshunov, Alexander D. ^{[1
]}

Egorov, Mikhail P. ^{[1
]}

机构：

[1] ND Zelinskii Inst Organ Chem, Leninsky Prospect 47, Moscow 119991, Russia

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

Electrocatalysis; Cascade reaction; Undivided cell; Pyrazoline-5-ones; Activated olefins; Spirocyclopropylpyrazolones; REVERSE-TRANSCRIPTASE INHIBITORS; ELECTROCHEMICAL TRANSFORMATION; ORGANIC ELECTROSYNTHESIS; BIOLOGICAL EVALUATIONS; MALONATE; MALONONITRILE; ALKYLIDENECYANOACETATES; ARYLIDENEMALONONITRILES; OXINDOLES; DESIGN;

D O I：

10.1007/s11164-015-2142-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The electrolysis of pyrazoline-5-ones and activated olefins in the presence of sodium bromide as mediator in alcohols in an undivided cell results in efficient formation of the substituted spirocyclopropylpyrazolones in 50-85 % yields. This novel electrocatalytic process opens a convenient way to functionalized spirocyclopropylpyrazolones-the promising compounds for the different biomedical applications. Thus, the simple electrocatalytic system can produce in an undivided cell under mild conditions the electrochemically induced cascade reaction of pyrazoline-5-ones with activated olefins.

引用

页码：2191 / 2200

页数：10

共 23 条

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