Nickel-Catalyzed, Regio- and Enantioselective Benzylic Alkenylation of Olefins with Alkenyl Bromide

被引：77

作者：

Liu, Jiandong ^{[1
]}

Gong, Hegui ^{[1
]}

Zhu, Shaolin ^{[2
]}

机构：

[1] Shanghai Univ, Sch Mat Sci & Engn, Ctr Supramol Chem & Catalysis, Dept Chem, Shanghai 200444, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Jiangsu Key Lab Adv Organ Mat Chem & Biomed, Nanjing 210093, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 08期

关键词：

alkenes; alkenylation; asymmetric catalysis; isomerization; nickel; LINEAR-SELECTIVE HYDROARYLATION; SECONDARY ALKYL ELECTROPHILES; COUPLING REACTIONS; CROSS-COUPLINGS; ISOMERIZATION-HYDROBORATION; REMOTE; HALIDES; FUNCTIONALIZATION; ARYLATION; VINYL;

D O I：

10.1002/anie.202012614

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A NiH-catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.

引用

页码：4060 / 4064

页数：5

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