In vitro activity of cefepime and cefotaxime compared to six other agents against 350 penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae

被引：0

作者：

Gomez-Lus, R ^{[1
]}

Navarro, C ^{[1
]}

Egido, P ^{[1
]}

Aspiroz, C ^{[1
]}

Goñi, P ^{[1
]}

Vergara, Y ^{[1
]}

Garcia, C ^{[1
]}

Duran, E ^{[1
]}

Castillo, J ^{[1
]}

Rubio, MC ^{[1
]}

机构：

[1] Univ Hosp Lozano Blesa, Dept Microbiol, Zaragoza, Spain

来源：

JOURNAL OF CHEMOTHERAPY | 2000年 / 12卷 / 01期

关键词：

Streptococcus pneumoniae; fourth generation cephaloporins; cefepime; cefotaxime;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

From January 1996 to December 1997, we evaluated the in vitro activity of 8 antimicrobials (penicillin, amoxycillin, amoxycillin/clavulanate, cefuroxime, ceftazidime, cefepime, cefotaxime, and imipenem) against 350 Streptococcus pneumoniae clinical isolates collected from two hospitals. Imipenem, cefepime and cefotaxime were the most active antibiotics against penicillin-intermediate (PI) and highly penicillin-resistant (PR) S. pneumoniae with MICs 2- to 8-fold lower than penicillin. Against PI and PR pneumococci amoxycillin and amoxycillin/clavulanate were 2-times less active than cefepime and cefotaxime, while cefuroxime was 4-8-times less active. The majority of strains of serotypes 6B, 23F, 14, 9 and 19 were penicillin-resistant, both intermediate (68%) and highly resistant (32%).

引用

页码：17 / 21

页数：5

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