Influence of internal globus pallidus stimulation on motor cortex activation pattern in Parkinson's disease

被引:18
作者
Devos, D
Derambure, P
Bourriez, JL
Cassim, DF
Blond, S
Guieu, JD
Destée, A
Defebvre, L [1 ]
机构
[1] CHRU, Hop R Salengro, Dept Neurol, Clin Neurol, F-59037 Lille, France
[2] CHRU, Hop R Salengro, Dept Neurophysiol, F-59037 Lille, France
[3] CHRU, Hop R Salengro, Dept Neurosurg, F-59037 Lille, France
关键词
Parkinson's disease; deep brain stimulation; internal pallidum; electroencephalogram; event-related desynchronization;
D O I
10.1016/S1388-2457(02)00112-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: Indications of the functional neurosurgical treatments become more and more numerous, however, few methods were used to study the mechanism of action and some discrepancies came to light. We assessed the influence of internal globus pallidus (GPI) stimulation and L-Dopa on cortical activation during the preparation and execution phases of the movement compared to clinical improvement of Parkinson's disease. Methods: We recorded the movement-related cortical potential and movement-related desynchronization. Results: The Unified Parkinson's Disease Rating Scale was improved by 46% under stimulation and 64% under stimulation with L-Dopa. Premovement desynchronization was significantly increased on central contralateral derivation under stimulation with L-Dopa and decreased on frontocentral ipsilateral derivation under stimulation with and without L-Dopa. Movement desynchronization was improved on the contralateral motor cortex under stimulation with and without L-Dopa (benefit correlated with bradykinesia improvement). The movement-related postmotor potential was significantly increased under stimulation with L-Dopa. Conclusions: GPI stimulation alone influenced the premotor cortex activation during the planning and induced a selective and focal effect on the organisation of motor cortical activity during the movement execution which may explain bradykinesia improvement. The motor cortex activation improvement under stimulation with L-Dopa concerned both the movement preparation and execution but remained very localised to the contralateral motor cortex. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:1110 / 1120
页数:11
相关论文
共 41 条
[1]  
Albin R L, 1995, Parkinsonism Relat Disord, V1, P3, DOI 10.1016/1353-8020(95)00011-T
[2]   Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study [J].
Baron, MS ;
Vitek, JL ;
Bakay, RAE ;
Green, J ;
Kaneoke, Y ;
Hashimoto, T ;
Turner, RS ;
Woodard, JL ;
Cole, SA ;
McDonald, WM ;
Delong, MR .
ANNALS OF NEUROLOGY, 1996, 40 (03) :355-366
[3]   Pallidal stimulation for Parkinson's disease - Two targets? [J].
Bejjani, B ;
Damier, P ;
Arnulf, I ;
Bonnet, AM ;
Vidailhet, M ;
Dormont, D ;
Pidoux, B ;
Cornu, P ;
Marsault, C ;
Agid, Y .
NEUROLOGY, 1997, 49 (06) :1564-1569
[4]  
Brown RG, 1999, ANN NEUROL, V45, P473, DOI 10.1002/1531-8249(199904)45:4<473::AID-ANA9>3.0.CO
[5]  
2-V
[6]   RANK TRANSFORMATIONS AS A BRIDGE BETWEEN PARAMETRIC AND NONPARAMETRIC STATISTICS [J].
CONOVER, WJ ;
IMAN, RL .
AMERICAN STATISTICIAN, 1981, 35 (03) :124-129
[7]   Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus [J].
Coubes, P ;
Roubertie, A ;
Vayssiere, N ;
Hemm, S ;
Echenne, B .
LANCET, 2000, 355 (9222) :2220-2221
[8]   Movement-related potentials in Parkinson's disease - Motor imagery and movement preparation [J].
Cunnington, R ;
Iansek, R ;
Johnson, KA ;
Bradshaw, JL .
BRAIN, 1997, 120 :1339-1353
[9]   Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms [J].
Davis, KD ;
Taub, E ;
Houle, S ;
Lang, AE ;
Dostrovsky, JO ;
Tasker, RR ;
Lozano, AM .
NATURE MEDICINE, 1997, 3 (06) :671-674
[10]   Movement related desynchronisation pattern preceding voluntary movement in untreated Parkinson's disease [J].
Defebvre, L ;
Bourriez, JL ;
Destee, A ;
Guieu, JD .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 60 (03) :307-312