MicroRNAs in Osteosarcomagenesis

被引：20
作者：
Kafchinski, Lisa A. [1 ,2 ]
Jones, Kevin B. [1 ,2 ]
机构：
[1] Univ Utah, Dept Orthopaed, Salt Lake City, UT 84132 USA
[2] Univ Utah, Huntsman Canc Inst, Ctr Childrens Canc Res, Salt Lake City, UT USA
来源：
CURRENT ADVANCES IN OSTEOSARCOMA | 2014年 / 804卷
关键词：
MircoRNA; miRNA; Prognosis; Apoptosis; Chemoresponsiveness; INHIBITS CELL-PROLIFERATION; COLON-CANCER CELLS; DOWN-REGULATION; PROMOTES APOPTOSIS; MIR-17-92; CLUSTER; TUMOR-SUPPRESSOR; POOR-PROGNOSIS; GROWTH-FACTOR; EXPRESSION; INVASION;
D O I：
10.1007/978-3-319-04843-7_6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The etiology of osteosarcoma (OS) remains enigmatic. Particular clinical and molecular patterns, observed with high frequency in OS, suggest that it results from some yet-to-be-discovered central driver. How else can biology generate such an aggressive, metastatic, genetically and chromosomally unstable malignancy with virtually no apparent precursor neoplasms that are partway along a disease path toward OS? With this conundrum as a backdrop, the discovery of every new native molecule with power to impact a cell's biology is usually quickly followed by a search to see if this type of molecule contains the key to unlock OS biology.
引用
收藏
页码：119 / 127
页数：9
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