Antimicrobial and SOD activities of novel transition metal ternary complexes of iminodiacetic acid containing α-diimine as auxiliary ligand

Ternary complexes containing an alpha-diimine auxiliary ligand have been widely used as models for several mono and polynuclear metal enzymes. The present ternary complexes [M(IDA)(Phen)H(2)O]center dot xH(2)O (x = 2,3 or 4) were prepared as novel antimicrobial agents employing reactions of Cu(OAc)(2) or MCl(2) (M = Co, Ni, Cr) with iminodiacetic acid (H(2)IDA) in the presence of 1,10-phenanthroline (Phen), whose chemical structure and bonding were elucidated by IR, FAB-Mass, (1)H, (13)C NMR, EPR spectral and elemental analyses. The antimicrobial activities against Escherichia coli (K-12), Bacillus subtilis (MTCC 121), Staphylococcus aureus (IOA-SA-22), Salmonella typhimurium (MTCC 98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei (isolates from Department of Microbiology, Faculty of Agricultural Science, AMU) were investigated and significant activities were obtained. The superoxide dismutase activity of the Cu(II) complex was assessed by NBT assay, The single crystal X-ray structure for [Cu(IDA) (Phen)H(2)O]center dot 2H(2)O indicates a triclinic unit cell in P-1 space group with structural parameters, a = 6.745(5), b = 10.551(5), c = 11.414(5) angstrom, a = 95.770(5), beta = 91.396(5), gamma = 92.518(5)degrees and presence of an extensive H-bonding and pi-pi stacking interactions which generate a supramolecular framework. (C) 2009 Elsevier Masson SAS. All rights reserved.