Analysis of Li-Fraumeni syndrome and Li-Fraumeni-like families for germline mutations in Bcl10

被引：9
作者：
Stone, JG
Eeles, RA
Sodha, N
Murday, V
Sheriden, E
Houlston, RS [1 ]
机构：
[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England
[2] Univ London St Georges Hosp, London SW17 0RE, England
[3] St James Hosp, Leeds LS9 7TF, W Yorkshire, England
来源：
CANCER LETTERS | 1999年 / 147卷 / 1-2期
关键词：
Li-Fraumeni syndrome; Bcl-10;
D O I：
10.1016/S0304-3835(99)00291-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Li-Fraumeni syndrome (LFS) is a dominant disease whose hallmark is an increased risk of breast cancers, brain tumours, sarcomas, leukaemia and adrenal carcinoma. Some, but not all LFS and Li-Fraumeni-like (LFL) families are caused by TP53 mutations. Bcl10 is a recently identified tumour suppressor reported to be commonly mutated in a wide range of cancers, To investigate the possibility that Bcl10 is a susceptibility gene for LFS and LFL we have analysed 27 LFS/LFL families. No mutations were observed. This indicates that Bcl10 is unlikely to act as a susceptibility gene for LFS and LFL. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：181 / 185
页数：5
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