Paroxetine associated hepatotoxicity: A report of 3 cases and a review of the literature

被引：33

作者：

Azaz-Livshits, T ^{[1
]}

Hershko, A ^{[1
]}

Ben-Chetrit, E ^{[1
]}

机构：

[1] Hadassah Univ Hosp, Dept Med & Clin Pharmacol, IL-91120 Jerusalem, Israel

来源：

PHARMACOPSYCHIATRY | 2002年 / 35卷 / 03期

关键词：

D O I：

10.1055/s-2002-31515

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We recently encountered 3 patients who had developed reversible paroxetine-associated hepatotoxicity. Two of the patients were over 80 years old and their hepatitis was accompanied by hyponatremia. In the third case, hepatitis was associated with multiple Organ failure and the co-administration of trazodone. Here, we will discuss the possible role Of preexisting Fisk factors in the development of paroxetine hepatotoxicity and review the relevant literature.

引用

页码：112 / 115

页数：4

共 23 条

[1] BECK PL, 1993, ANN INTERN MED, V118, P10
[2] Benbow SJ, 1997, BRIT MED J, V314, P1387
[3] BOYER WF, 1992, J CLIN PSYCHIAT, V53, P61
[4] TRAZODONE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN DEPRESSION AND ANXIETY
BROGDEN, RN
HEEL, RC
SPEIGHT, TM
AVERY, GS
[J]. DRUGS, 1981, 21 (06) : 401 - 429
[5] CONCENTRATION-RELATED CHANGES IN BLOOD AND TISSUE PARAMETERS OF HEPATOTOXICITY AND THEIR INTERDEPENDENCE IN RATS EXPOSED TO BROMOBENZENE AND 1,2-DICHLOROBENZENE
BRONDEAU, MT
BAN, M
BONNET, P
GUENIER, JP
DECEAURRIZ, J
[J]. TOXICOLOGY LETTERS, 1986, 31 (02) : 159 - 166
[6] Atrium and paroxetine-related severe hepatitis
Cadranel, JF
Di Martino, V
Cazier, A
Pras, V
Bachmeyer, C
Olympio, P
Gonzenbach, A
Mofredj, A
Coutarel, P
Devergie, B
Biour, M
[J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 1999, 28 (01) : 52 - 55
[7] TRAZODONE AND LIVER TOXICITY
CHU, AG
GUNSOLLY, BL
SUMMERS, RW
ALEXANDER, B
MCCHESNEY, C
TANNA, VL
[J]. ANNALS OF INTERNAL MEDICINE, 1983, 99 (01) : 128 - 129
[8] THE PHARMACOKINETICS OF PAROXETINE IN RENAL IMPAIRMENT
DOYLE, GD
LAHER, M
KELLY, JG
BYRNE, MM
CLARKSON, A
ZUSSMAN, BD
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1989, 80 : 89 - 90
[9] A COMPARISON OF PAROXETINE AND PLACEBO IN DEPRESSED OUTPATIENTS
DUNBAR, GC
CLAGHORN, JL
KIEV, A
RICKELS, K
SMITH, WT
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1993, 87 (05) : 302 - 305
[10] Fenichel RR, 1996, NEW ENGL J MED, V334, P864

← 1 2 3 →