Interleukin-8-induced human peripheral blood B-lymphocyte chemotaxis in vitro

被引：18

作者：

Schratzberger, P ^{[1
]}

Dunzendorfer, S ^{[1
]}

Reinisch, N ^{[1
]}

Kahler, CM ^{[1
]}

Wiedermann, CJ ^{[1
]}

机构：

[1] UNIV INNSBRUCK, DEPT INTERNAL MED, LAB INTENS CARE MED, A-6020 INNSBRUCK, AUSTRIA

来源：

IMMUNOLOGY LETTERS | 1997年 / 58卷 / 03期

基金：

奥地利科学基金会;

关键词：

chemotaxis; T-cells; B-cells; inflammatory mediators; chemokines; magnetic cell sorting;

D O I：

10.1016/S0165-2478(97)00085-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied chemotactic effects of interleukin-8 (IL-8) on human peripheral blood lymphocytes (PBL) using micropore filler assays. As identification of chemotactic responses depends on the status of activation of cells, magnetic cell sorting (MACS) was performed providing freshly isolated B-lymphocytes of highest purify. B-lymphocytes responded chemotactically to IL-8 in a dose-dependent manner. We conclude that IL-8 may play a role in both T-and B-lymphocyte trafficking by acting directly on the cells. (C) 1997 Elsevier Science B.V.

引用

页码：167 / 170

页数：4

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