Altered taste preference and loss of limbic-projecting serotonergic neurons in the dorsal raphe nucleus of chronically epileptic rats

被引：11

作者：

Maia, Gisela H. ^{[1
,2
,4
,5
]}

Soares, Joana I. ^{[1
,2
,4
]}

Andrade, Pedro A. ^{[1
,2
,4
]}

Leite, Juliana F. ^{[5
]}

Luz, Liliana L. ^{[1
,2
]}

Andrade, Jose P. ^{[3
]}

Lukoyanov, Nikolai V. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Porto, Inst Invest & Inovacao Saude, P-4200319 Oporto, Portugal

[2] Univ Porto, Inst Biol Mol & Celular, P-4200319 Oporto, Portugal

[3] Univ Porto, Fac Med, Dept Anat, P-4200319 Oporto, Portugal

[4] Univ Porto, Programa Doutoral Neurociencias, P-4200319 Oporto, Portugal

[5] Medibrain Ctr Estudos Neurofisiol, Vila Do Conde, Portugal

来源：

BEHAVIOURAL BRAIN RESEARCH | 2016年 / 297卷

关键词：

Epilepsy; Depression; Interfascicular nucleus; 5-Hydroxytriptophan; Kainic acid; Stereology; TEMPORAL-LOBE EPILEPSY; MAJOR DEPRESSION; 1A RECEPTORS; PSYCHIATRIC COMORBIDITY; BEHAVIORAL ALTERATIONS; NEUROTROPHIC FACTOR; PILOCARPINE MODEL; ANIMAL-MODEL; STRESS; BRAIN;

D O I：

10.1016/j.bbr.2015.10.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Mood disorders and major depression are frequently comorbid with epilepsy. While the nature of this comorbidity is not fully understood, multiple lines of evidence suggest that changes in serotonin (5-HT) neurotransmission may be an underlying mechanism. In this study, we tested the hypothesis that chronic epilepsy in rats can be associated with loss of 5-HT neurons in the dorsal raphe (DR) nuclear complex, the main source of 5-HT projections to the cerebral cortex, which would help to explain respective behavioral deficits. Epilepsy was induced using the kainate model of status epilepticus in adult Wistar rats. After a 3-month recovery period, all kainate-treated rats that had experienced status epilepticus showed spontaneous seizures and reduced sucrose preference (anhedonia), a core symptom of depression. No changes in the forced swim test were detected. The total numbers of 5-HT immunoreactive cells were estimated in all DR subdivisions of control and epileptic rats. Interestingly, epilepsy-related loss of 5-HT neurons (approximately 35%) was observed only in the interfascicular part of the DR complex, which is known to innervate brain regions involved in depression. These findings support the notion that mental health impairments observed in epilepsy may be related to loss of a specific population of the DR 5-HT neurons projecting to limbic brain areas. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：28 / 36

页数：9

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