Mathematical neuroscience: from neurons to circuits to systems

被引:40
作者
Gutkin, B [1 ]
Pinto, D [1 ]
Ermentrout, B [1 ]
机构
[1] Brown Univ, Div Biol & Med, Dept Neurosci, Providence, RI 02912 USA
关键词
mathematical models; non-linear dynamics; barrel cortex; spike-time statistics; hallucinations;
D O I
10.1016/j.jphysparis.2003.09.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Applications of mathematics and computational techniques to Our understanding Of neuronal systems are provided. Reduction of membrane models to simplified canonical models demonstrates how neuronal spike-time statistics follow from simple properties of neurons. Averaging over space allows one to derive a simple model for the whisker barrel circuit. and use this to explain and suggest several experiments. Spatio-temporal pattern formation methods are applied to explain the patterns seen in the early stages of drug-induced visual hallucinations. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:209 / 219
页数:11
相关论文
共 34 条
[1]   Geometric visual hallucinations, Euclidean symmetry and the functional architecture of striate cortex [J].
Bressloff, PC ;
Cowan, JD ;
Golubitsky, M ;
Thomas, PJ ;
Wiener, MC .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 356 (1407) :299-330
[2]   Neural networks as spatio-temporal pattern-forming systems [J].
Ermentrout, B .
REPORTS ON PROGRESS IN PHYSICS, 1998, 61 (04) :353-430
[3]   The effects of spike frequency adaptation and negative feedback on the synchronization of neural oscillators [J].
Ermentrout, B ;
Pascal, M ;
Gutkin, B .
NEURAL COMPUTATION, 2001, 13 (06) :1285-1310
[4]   MATHEMATICAL-THEORY OF VISUAL HALLUCINATION PATTERNS [J].
ERMENTROUT, GB ;
COWAN, JD .
BIOLOGICAL CYBERNETICS, 1979, 34 (03) :137-150
[5]   Spike generating dynamics and the conditions for spike-time precision in cortical neurons [J].
Gutkin, B ;
Ermentrout, GB ;
Rudolph, M .
JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2003, 15 (01) :91-103
[6]   Dynamics of membrane excitability determine interspike interval variability: A link between spike generation mechanisms and cortical spike train statistics [J].
Gutkin, BS ;
Ermentrout, GB .
NEURAL COMPUTATION, 1998, 10 (05) :1047-1065
[7]  
GUTKIN BS, UNPUB NEURONS MULTIP
[8]  
HEDGES K, 1981, AM INDIAN ROCK ART, V7
[9]  
HEDGES K, 1981, AM INDIAN ROCK ART, V8
[10]   A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE [J].
HODGKIN, AL ;
HUXLEY, AF .
JOURNAL OF PHYSIOLOGY-LONDON, 1952, 117 (04) :500-544