A Borrowing Hydrogen Approach to the Synthesis of RS-67,333

被引：2

作者：

Carbonnel, Elodie ^{[1
]}

Alix, Florent ^{[1
]}

Gembus, Vincent ^{[1
]}

机构：

[1] IRCOF, VFP Therapies, R&D Lab, Rue Tesniere, F-76131 Mont St Aignan, France

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 09期

关键词：

iridium; catalysis; hydrogen transfer; alcohols; heterocycles; 5-HT4 RECEPTOR AGONISTS; METAL-CATALYZED DEHYDROGENATION; ASTERISK-LR COMPLEX; ALPHA-ALKYLATION; ALZHEIMERS-DISEASE; OBJECT RECOGNITION; ALCOHOLS; KETONES; SEROTONIN; MEMORY;

D O I：

10.1055/s-0036-1588133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy using the borrowing hydrogen methodology to access the 5-HT4R agonist RS-67,333 is presented. Especially, this selective and highly potent ligand of 5-HT4 receptor was obtained quickly and efficiently by catalytic alkylation of a ketone with various alcohols in the presence of a catalytic amount of (Cp*IrCl2)(2).

引用

页码：2057 / 2062

页数：6

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