Extravesical Pagetoid Spread of Urothelial Carcinoma in Situ A Report of Five Cases

被引：0

作者：

Akgul, Mahmut ^{[1
]}

Bomeisl, Phillip B. ^{[1
]}

MacLennan, Gregory T. ^{[1
]}

机构：

[1] Univ Hosp Cleveland, Case Med Ctr, Dept Pathol, Cleveland, OH 44106 USA

来源：

ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY | 2015年 / 37卷 / 06期

关键词：

bladder; carcinoma in situ; cystoscopy; pagetoid spread; prostatic duct; seminal vesicles; urachus; urinary bladder; urothelial carcinoma; vagina; TRANSITIONAL-CELL CARCINOMA; URINARY-BLADDER; DISEASE; LESIONS;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

BACKGROUND: Urothelial carcinoma in situ (CIS) of the bladder is classified as a flat lesion of the urothelium; it has a tendency to be multifocal and carries a high risk of recurrence and persistence. Approximately one-third of patients with urothelial CIS of the bladder develop invasive carcinoma if left untreated. There are a few reported cases of extravesical intramucosal extension (pagetoid spread) of urothelial CIS without prior documentation of primary muscle-invasive carcinoma. CASES: We present 5 cases of urothelial CIS that exhibited pagetoid spread to prostatic ducts, seminal vesicles, and the vagina. CONCLUSION: Pagetoid spread of urothelial CIS of the bladder may introduce uncertainty with regard to assignment of proper disease staging, and therefore uncertainty about appropriate cancer management.

引用

页码：364 / 368

页数：5

共 17 条

[1] Transitional cell carcinoma of the bladder mimicking recurrent Paget's disease of the vulva: Report of two gases, with one occurring in a myocutaneous flap [J].

Boardman, CH ;

Webb, MJ ;

Cheville, JC ;

Lerner, SE ;

Zincke, H .

GYNECOLOGIC ONCOLOGY, 2001, 82 (01) :200-204

[2]

Cheng L, 2000, CANCER, V88, P625, DOI 10.1002/(SICI)1097-0142(20000201)88:3<625::AID-CNCR20>3.3.CO

[3]

2-1

[4]

Cheng L, 2014, UROLOGIC SURG PATHOL, P236

[5] Staging and reporting of urothelial carcinoma of the urinary bladder [J].

Cheng, Liang ;

Montironi, Rodolfo ;

Davidson, Darrell D. ;

Lopez-Beltran, Antonio .

MODERN PATHOLOGY, 2009, 22 :S70-S95

[6]

Epstein J, 2010, BIOPSY INTERPRETATIO, P25

[7] Pagetoid spread of urothelial carcinoma in the epidermis surrounding a ureterocutaneostomy [J].

Ishida, Mitsuaki ;

Okabe, Hidetoshi .

JOURNAL OF CUTANEOUS PATHOLOGY, 2013, 40 (08) :775-776

[8] Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation [J].

Lopez-Beltran, A ;

Cheng, L ;

Andersson, L ;

Brausi, M ;

de Matteis, A ;

Montironi, R ;

Sesterhenn, I ;

van der Kwast, T ;

Mazerolles, C .

VIRCHOWS ARCHIV, 2002, 440 (01) :3-11

[9]

Lu Bingjian, 2015, J Low Genit Tract Dis, V19, pe13, DOI 10.1097/LGT.0000000000000020

[10]

MELAMED MR, 1964, CANCER-AM CANCER SOC, V17, P1533, DOI 10.1002/1097-0142(196412)17:12<1533::AID-CNCR2820171205>3.0.CO

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