Molecular characterization and an 80-bp indel polymorphism within the prolactin receptor (PRLR) gene and its associations with chicken growth and carcass traits

被引：20

作者：

Liang, Ke ^{[1
]}

Wang, Xiangnan ^{[1
]}

Tian, Xiaoxiao ^{[1
]}

Geng, Rui ^{[1
]}

Li, Wenya ^{[1
]}

Jing, Zhenzhu ^{[1
]}

Han, Ruili ^{[1
]}

Tian, Yadong ^{[1
]}

Liu, Xiaojun ^{[1
]}

Kang, Xiangtao ^{[1
]}

Li, Zhuanjian ^{[1
]}

机构：

[1] Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou 450046, Henan, Peoples R China

来源：

3 BIOTECH | 2019年 / 9卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Prolactin receptor; Association analysis; Growth traits; Insertion; deletion; Genetic differentiation; SINGLE-NUCLEOTIDE POLYMORPHISMS; LITTER SIZE; INSERTION/DELETION INDEL; MESSENGER-RNA; EXPRESSION; PERFORMANCE; MUTATION; DELETION; GLAND;

D O I：

10.1007/s13205-019-1827-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The prolactin receptor (PRLR), a type I cytokine receptor, must bind prolactin (PRL) to act on target cells to mediate various physiological functions, including reproduction and lactation. This study identified an 80-bp insertion/deletion (indel) polymorphism in the 3 '-untranslated region (3 '-UTR) of the chicken PRLR gene in 3736 individuals from 15 breeds and analyzed its associations with growth and carcass traits in an F-2 resource population. The results of the association analysis indicated that the 80-bp indel polymorphism was significantly (P<0.05) or very significantly (P<0.01) associated with multiple growth and carcass traits, such as body weight, leg weight, and shank length. In addition, we found that during the breeding process of commercial laying hens and commercial broilers, the 80-bp indel locus was artificially selected for the II genotype. Together, our findings reveal that this 80-bp indel polymorphism has potential as a new molecular marker for marker-assisted selection of chicken growth and carcass traits.

引用

页数：10

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