Two Takayasu arteritis patients successfully treated with rituximab

被引：29

作者：

Caltran, E. ^{[1
]}

Di Colo, G. ^{[1
]}

Ghigliotti, G. ^{[2
]}

Capecchi, R. ^{[1
]}

Catarsi, E. ^{[1
]}

Puxeddu, I. ^{[1
]}

Migliorini, P. ^{[1
]}

Tavoni, A. ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Clin Immunol Unit, I-56126 Pisa, Italy

[2] Univ Genoa, Dept Internal Med, Cardiol Unit, I-16126 Genoa, Italy

来源：

CLINICAL RHEUMATOLOGY | 2014年 / 33卷 / 08期

关键词：

B lymphocytes; Rituximab; Takayasu arteritis; THERAPY;

D O I：

10.1007/s10067-014-2506-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Takayasu arteritis (TA) is a rare form of chronic large vessel vasculitis of unknown origin involving the aorta and its major branches. Recently, the involvement of B lymphocytes in TA has been suggested, and active refractory TA patients were successfully treated with B cell depletion therapy (BCDT). We report two cases of patients with TA successfully treated with anti-CD20 monoclonal antibody (rituximab). The favorable outcome of rituximab treatment in our patients also support the view that BCDT can be a useful option for refractory TA, and its potential should be evaluated in controlled trials.

引用

页码：1183 / 1184

页数：2

共 11 条

[1] Pathogenesis of Takayasu's arteritis: A 2011 update [J].

Arnaud, Laurent ;

Haroche, Julien ;

Mathian, Alexis ;

Gorochov, Guy ;

Amoura, Zahir .

AUTOIMMUNITY REVIEWS, 2011, 11 (01) :61-67

[2] Anti TNF-α in refractory Takayasu's arteritis: Cases series and review of the literature [J].

Comarmond, Cloe ;

Plaisier, Emmanuel ;

Dahan, Karine ;

Mirault, Tristan ;

Emmerich, Joseph ;

Amoura, Zahir ;

Cacoub, Patrice ;

Saadoun, David .

AUTOIMMUNITY REVIEWS, 2012, 11 (09) :678-684

[3] Should rituximab be considered as the first-choice treatment for severe autoimmune rheumatic diseases? [J].

Galarza, Claudio ;

Valencia, Diana ;

Tobon, Gabriel J. ;

Zurita, Luis ;

Mantilla, Ruben D. ;

Pineda-Tamayo, Ricardo ;

Rojas-Villarraga, Adriana ;

Rueda, Juan C. ;

Anaya, Juan-Manuel .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2008, 34 (01) :124-128

[4] Anti-tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis [J].

Hoffman, GS ;

Merkel, PA ;

Brasington, RD ;

Lenschow, DJ ;

Liang, P .

ARTHRITIS AND RHEUMATISM, 2004, 50 (07) :2296-2304

[5] Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab [J].

Hoyer, Bimba F. ;

Mumtaz, Imtiaz M. ;

Loddenkemper, Konstanze ;

Bruns, Anne ;

Sengler, Claudia ;

Hermann, Kay-Geert ;

Maza, Sofiane ;

Keitzer, Rolf ;

Burmester, Gerd-Ruediger ;

Buttgereit, Frank ;

Radbruch, Andreas ;

Hiepe, Falk .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (01) :75-79

[6] Immunophenotypic analysis of the aortic wall in Takayasu's arteritis: involvement of lymphocytes. dendritic cells and granulocytes in immunoinflammatory reactions [J].

Inder, SJ ;

Bobryshev, YV ;

Cherian, SM ;

Wang, AY ;

Lord, RSA ;

Masuda, K ;

Yutani, C .

CARDIOVASCULAR SURGERY, 2000, 8 (02) :141-148

[7] Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody [J].

Nishimoto, Norihiro ;

Nakahara, Hideko ;

Yoshio-Hoshino, Naoko ;

Mima, Toru .

ARTHRITIS AND RHEUMATISM, 2008, 58 (04) :1197-1200

[8]

Quartuccio L, 2012, CLIN EXP RHEUMATOL, V30, P922

[9] Tocilizumab: a novel therapy for patients with large-vessel vasculitis [J].

Salvarani, Carlo ;

Magnani, Luca ;

Catanoso, Mariagrazia ;

Pipitone, Nicolo ;

Versari, Annibale ;

Dardani, Lucia ;

Pulsatelli, Lia ;

Meliconi, Riccardo ;

Boiardi, Luigi .

RHEUMATOLOGY, 2012, 51 (01) :151-156

[10] Diagnostic criteria for Takayasu arteritis [J].

Sharma, BK ;

Jain, S ;

Suri, S ;

Numano, F .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1996, 54 :S141-S147

← 1 2 →