Dendritic Cell Lectin-Targeting Sentinel-like Unimolecular Glycoconjugates To Release an Anti-HIV Drug

被引：136
作者：
Zhang, Qiang [1 ]
Su, Lu [2 ,3 ]
Collins, Jennifer [1 ]
Chen, Guosong [2 ,3 ]
Wallis, Russell [4 ]
Mitchell, Daniel A. [5 ]
Haddleton, David M. [1 ]
Becer, C. Remzi [1 ,6 ]
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] Fudan Univ, Minist Educ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
[3] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China
[4] Univ Leicester, Dept Biochem, Leicester LE1 9HN, Leics, England
[5] Univ Warwick, Warwick Med Sch, Clin Sci Res Labs, Coventry CV2 2DX, W Midlands, England
[6] Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 11期
关键词：
CHAIN-TRANSFER POLYMERIZATION; BETA-CYCLODEXTRIN CORE; DC-SIGN; CARBOHYDRATE-RECOGNITION; PROTEIN INTERACTIONS; CLICK CHEMISTRY; STAR POLYMERS; BINDING; GLYCOPOLYMERS; OLIGOSACCHARIDE;
D O I：
10.1021/ja4131565
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.
引用
收藏
页码：4325 / 4332
页数：8
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