Microbial Unmasking of Plant Glycosides

被引：9

作者：

Biernat, Kristen A. ^{[1
]}

Li, Bo ^{[1
]}

Redinbo, Matthew R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Biochem, Chapel Hill, NC 27599 USA

来源：

MBIO | 2018年 / 9卷 / 01期

关键词：

enzymes; gut microbiota; plant glycosides; FOOD;

D O I：

10.1128/mBio.02433-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio 8: e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17) describe how one gut microbe, Lactobacillus acidophilus, catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host.

引用

页数：4

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