The Carbapenemase-Producing Klebsiella pneumoniae Population Is Distinct and More Clonal than the CarbapenemSusceptible Population

被引：23

作者：

Esteban-Cantos, Andres ^{[1
]}

Aracil, Belen ^{[1
,2
]}

Bautista, Veronica ^{[1
]}

Ortega, Adriana ^{[1
,2
]}

Lara, Noelia ^{[1
]}

Saez, David ^{[1
]}

Fernandez-Romero, Sara ^{[1
]}

Perez-Vazquez, Maria ^{[1
,2
]}

Navarro, Ferran ^{[2
,3
]}

Grundmann, Hajo ^{[4
]}

Campos, Jose ^{[1
,2
]}

Oteo, Jesus ^{[1
,2
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Lab Referencia & Invest Resistencia Antibiot & In, Madrid, Spain

[2] REIPI, Seville, Spain

[3] Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau, Microbiol Serv, Barcelona, Spain

[4] Univ Freiburg, Fac Med, Dept Infect Prevent & Hosp Hyg, Freiburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 04期

关键词：

carbapenem resistance; population structure; MLST; carbapenemases; Klebsiella pneumoniae; ESCHERICHIA-COLI; DISSEMINATION; PATHOGENS;

D O I：

10.1128/AAC.02520-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied in parallel the population structure of 90 carbapenemaseproducing and 88 carbapenemase-susceptible Klebsiella pneumoniae isolates collected in 20 Spanish hospitals, in the context of the EuSCAPE project. Fourteen and 50 multilocus sequence types (MLSTs) were detected among the carbapenemase-producing and carbapenem-susceptible isolates, respectively. ST11 and ST15 clones were more frequent in the carbapenemase-producing group than in the carbapenemase-susceptible group (P < 0.0001). Among the members of the carbapenem-suceptible group, the cefotaxime-resistant population showed population parameters that differed between the populations of the wild-type strains and the carbapenemase producers.

引用

页数：5

共 15 条

[1] Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015 [J].

Albiger, B. ;

Glasner, C. ;

Struelens, M. J. ;

Grundmann, H. ;

Monnet, D. L. .

EUROSURVEILLANCE, 2015, 20 (45) :17-34

[2]

[Anonymous], 2013, EUROSURVEILLANCE

[3]

Coque T M, 2008, Euro Surveill, V13

[4] Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates [J].

Diancourt, L ;

Passet, V ;

Verhoef, J ;

Grimont, PAD ;

Brisse, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :4178-4182

[5] Correlation between the genetic diversity of nosocomial pathogens and their survival time in intensive care units [J].

Gastmeier, P ;

Schwab, F ;

Bärwolff, S ;

Rüden, H ;

Grundmann, H .

JOURNAL OF HOSPITAL INFECTION, 2006, 62 (02) :181-186

[6]

Grundmann H, 2016, LANCET INFECT DIS

[7] Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods [J].

Lee, Chang-Ro ;

Lee, Jung Hun ;

Park, Kwang Seung ;

Kim, Young Bae ;

Jeong, Byeong Chul ;

Lee, Sang Hee .

FRONTIERS IN MICROBIOLOGY, 2016, 7

[8]

Lopez-Cerero Lorena, 2014, Enferm Infecc Microbiol Clin, V32 Suppl 4, P10, DOI 10.1016/S0213-005X(14)70169-7

[9] Rapid Detection of Carbapenemase-producing Enterobacteriaceae [J].

Nordmann, Patrice ;

Poirel, Laurent ;

Dortet, Laurent .

EMERGING INFECTIOUS DISEASES, 2012, 18 (09) :1503-1507

[10] Carbapenemase-producing Escherichia coli is becoming more prevalent in Spain mainly because of the polyclonal dissemination of OXA-48 [J].

Ortega, Adriana ;

Saez, David ;

Bautista, Veronica ;

Fernandez-Romero, Sara ;

Lara, Noelia ;

Aracil, Belen ;

Perez-Vazquez, Maria ;

Campos, Jose ;

Oteo, Jesus .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (08) :2131-2138

← 1 2 →