Synthesis of 7-arylquinolinones and 6-arylindoles from 3-aminobiphenyls through regioselective cyclization reactions

被引：7
作者：
Hammer, Sebastian G. [1 ]
Heinrich, Markus R. [1 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91052 Erlangen, Germany
来源：
TETRAHEDRON | 2014年 / 70卷 / 43期
关键词：
Quinolinones; Aminobiphenyls; Cyclizations; Cinnamic amides; Heterocycles; EFFICIENT SYNTHESIS; PALLADIUM; CATALYSTS; ANILINES; LIGANDS; AMINO;
D O I：
10.1016/j.tet.2014.08.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
7-Arylquinolinones were obtained in two steps from 3-aminobiphenyls through conversion into cinnamic amides. The highly regioselective cyclization under elimination of anisole proceeded in the presence of phosphoric acid and phosphorous pentoxide. 6-Arylindoles were accessible, although in lower yields, from 3-aminobiphenyls via 3-(biphenylamino)acrylates and palladium-catalyzed cyclization reactions. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8114 / 8121
页数：8
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