Synthesis of 7-arylquinolinones and 6-arylindoles from 3-aminobiphenyls through regioselective cyclization reactions

被引：7

作者：

Hammer, Sebastian G. ^{[1
]}

Heinrich, Markus R. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91052 Erlangen, Germany

来源：

TETRAHEDRON | 2014年 / 70卷 / 43期

关键词：

Quinolinones; Aminobiphenyls; Cyclizations; Cinnamic amides; Heterocycles; EFFICIENT SYNTHESIS; PALLADIUM; CATALYSTS; ANILINES; LIGANDS; AMINO;

D O I：

10.1016/j.tet.2014.08.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7-Arylquinolinones were obtained in two steps from 3-aminobiphenyls through conversion into cinnamic amides. The highly regioselective cyclization under elimination of anisole proceeded in the presence of phosphoric acid and phosphorous pentoxide. 6-Arylindoles were accessible, although in lower yields, from 3-aminobiphenyls via 3-(biphenylamino)acrylates and palladium-catalyzed cyclization reactions. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：8114 / 8121

页数：8

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