Characterizing Cancer Subtypes Using Dual Analysis in Caleydo StratomeX

被引：16

作者：

Turkay, Cagatay ^{[1
]}

Lex, Alexander ^{[2
]}

Streit, Marc ^{[3
]}

Pfister, Hanspeter ^{[4
]}

Hauser, Helwig ^{[5
]}

机构：

[1] City Univ London, Dept Comp Sci, giCtr, London, England

[2] Harvard Univ, Sch Engn & Appl Sci, Visual Comp Grp, Cambridge, MA 02138 USA

[3] Johannes Kepler Univ Linz, Inst Comp Graph, A-4040 Linz, Austria

[4] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[5] Univ Bergen, Dept Informat, N-5020 Bergen, Norway

来源：

IEEE COMPUTER GRAPHICS AND APPLICATIONS | 2014年 / 34卷 / 02期

基金：

奥地利科学基金会;

关键词：

MICROARRAY DATA-ANALYSIS; VISUAL ANALYSIS;

D O I：

10.1109/MCG.2014.1

中图分类号：

TP31 [计算机软件];

学科分类号：

081202 ; 0835 ;

摘要：

In this approach, dual-analysis views depict distributions of genes or data samples within Caleydo. Significant-difference plots show the elements of a cancer subtype that differ significantly from other subtypes. Analysts can characterize subtypes, investigate how samples relate to their subtype and other groups, and create well-defined subtypes based on statistical properties.

引用

页码：38 / 47

页数：10

共 13 条

[1] Microarray data analysis: from disarray to consolidation and consensus [J].

Allison, DB ;

Cui, XQ ;

Page, GP ;

Sabripour, M .

NATURE REVIEWS GENETICS, 2006, 7 (01) :55-65

[2] Mayday - a microarray data analysis workbench [J].

Dietzsch, J ;

Gehlenborg, N ;

Nieselt, K .

BIOINFORMATICS, 2006, 22 (08) :1010-1012

[3] Comprehensive molecular portraits of human breast tumours [J].

Koboldt, Daniel C. ;

Fulton, Robert S. ;

McLellan, Michael D. ;

Schmidt, Heather ;

Kalicki-Veizer, Joelle ;

McMichael, Joshua F. ;

Fulton, Lucinda L. ;

Dooling, David J. ;

Ding, Li ;

Mardis, Elaine R. ;

Wilson, Richard K. ;

Ally, Adrian ;

Balasundaram, Miruna ;

Butterfield, Yaron S. N. ;

Carlsen, Rebecca ;

Carter, Candace ;

Chu, Andy ;

Chuah, Eric ;

Chun, Hye-Jung E. ;

Coope, Robin J. N. ;

Dhalla, Noreen ;

Guin, Ranabir ;

Hirst, Carrie ;

Hirst, Martin ;

Holt, Robert A. ;

Lee, Darlene ;

Li, Haiyan I. ;

Mayo, Michael ;

Moore, Richard A. ;

Mungall, Andrew J. ;

Pleasance, Erin ;

Robertson, A. Gordon ;

Schein, Jacqueline E. ;

Shafiei, Arash ;

Sipahimalani, Payal ;

Slobodan, Jared R. ;

Stoll, Dominik ;

Tam, Angela ;

Thiessen, Nina ;

Varhol, Richard J. ;

Wye, Natasja ;

Zeng, Thomas ;

Zhao, Yongjun ;

Birol, Inanc ;

Jones, Steven J. M. ;

Marra, Marco A. ;

Cherniack, Andrew D. ;

Saksena, Gordon ;

Onofrio, Robert C. ;

Pho, Nam H. .

NATURE, 2012, 490 (7418) :61-70

[4] Parallel sets: Interactive exploration and visual analysis of categorical data [J].

Kosara, R ;

Bendix, F ;

Hauser, H .

IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS, 2006, 12 (04) :558-568

[5] StratomeX: Visual Analysis of Large-Scale Heterogeneous Genomics Data for Cancer Subtype Characterization [J].

Lex, A. ;

Streit, M. ;

Schulz, H. -J. ;

Partl, C. ;

Schmalstieg, D. ;

Park, P. J. ;

Gehlenborg, N. .

COMPUTER GRAPHICS FORUM, 2012, 31 (03) :1175-1184

[6] VisBricks: Multiform Visualization of Large, Inhomogeneous Data [J].

Lex, Alexander ;

Schulz, Hans-Joerg ;

Streit, Marc ;

Partl, Christian ;

Schmalstieg, Dieter .

IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS, 2011, 17 (12) :2291-2300

[7]

Pournelle G. H., 1953, Journal of Mammalogy, V34, P133, DOI 10.1890/0012-9658(2002)083[1421:SDEOLC]2.0.CO

[8]

[9] Interactive Sankey diagrams [J].

Riehmann, P ;

Hanfler, M ;

Froehlich, B .

INFOVIS 05: IEEE SYMPOSIUM ON INFORMATION VISUALIZATION, PROCEEDINGS, 2005, :233-240

[10] The unequal variance t-test is an underused alternative to Student's t-test and the Mann-Whitney U test [J].

Ruxton, GD .

BEHAVIORAL ECOLOGY, 2006, 17 (04) :688-690

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