Near infrared fluorescent probe for in vivo bioimaging of endogenous hypochlorous acid

被引：37
作者：
Qian, Xiaoli [1 ]
Yu, Hui [1 ]
Zhu, Wenchao [1 ]
Yao, Xufeng [1 ]
Liu, Wangwang [1 ]
Yang, Shikui [1 ]
Zhou, Fangyuan [1 ]
Liu, Yi [1 ]
机构：
[1] China Pharmaceut Univ, Sch Engn, Nanjing 211198, Peoples R China
来源：
DYES AND PIGMENTS | 2021年 / 188卷
基金：
中国国家自然科学基金;
关键词：
NIR; Fluorescent probes; Hypochlorous acid; Bioimaging; In vivo; LIVING CELLS; ON PROBE; MITOCHONDRIA; LYSOSOME; VITRO;
D O I：
10.1016/j.dyepig.2021.109218
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Accurate detection of HOCl with high sensitivity and high selectivity is essential to elucidate its functions in health or disease states. Herein we propose a new fluorescence HOCl probe (NFL-S) by combining reasonable design strategies and dye screening methods. The probe NFL-S has fast response rate, excellent sensitivity (LOD = 35.0 nM) and outstanding selectivity toward HOCl. It has been successfully applied to detect endogenous HOCl produced by RAW264.7 cells, and further applied to oxidative stress imaging in a mouse arthritis model. Therefore, the probe NFL-S is highly promising to be useful for biological tool to disclose the roles of HOCl in different physiological and pathological contexts.
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页数：6
相关论文
共 36 条
[1]  
Ai XN, 2018, ANAL CHEM, V90, P4485, DOI [10.1021/acs.analchem.7b04833, 10.1021/acs.analchern.7b04833]
[2]   Solvent directed discrimination of metal ions using a coumarin-pyridine fluorescence receptor [J].
Cao, Zhiyuan ;
Fan, Xia ;
Yang, Zhiyu ;
Zhang, Xuebin ;
Ding, Ningxujin ;
Ding, Yubin ;
Zhang, Weihua .
SENSORS AND ACTUATORS B-CHEMICAL, 2020, 310
[3]   Bioluminescent Turn-On Probe for Sensing Hypochlorite in Vitro and in Tumors [J].
Chen, Peiyao ;
Zheng, Zhen ;
Zhu, Yunxia ;
Dong, Yu ;
Wang, Fuqiang ;
Liang, Gaolin .
ANALYTICAL CHEMISTRY, 2017, 89 (11) :5694-5697
[4]   Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species [J].
Chen, Xiaoqiang ;
Wang, Fang ;
Hyun, Ji Young ;
Wei, Tingwen ;
Qiang, Jian ;
Ren, Xintong ;
Shin, Injae ;
Yoon, Juyoung .
CHEMICAL SOCIETY REVIEWS, 2016, 45 (10) :2976-3016
[5]   Rational Design of a Hepatoma-Specific Fluorescent Probe for HOCl and Its Bioimaging Applications in Living HepG2 Cells [J].
Duan, Qingxia ;
Jia, Pan ;
Zhuang, Zihan ;
Liu, Caiyun ;
Zhang, Xue ;
Wang, Zuokai ;
Sheng, Wenlong ;
Li, Zilu ;
Zhu, Hanchuang ;
Zhu, Baocun ;
Zhang, Xiaoling .
ANALYTICAL CHEMISTRY, 2019, 91 (03) :2163-2168
[6]   Rational construction of probes rendering ratiometric response to the cancer-specific enzyme NQO1 [J].
Fei, Qiang ;
Zhou, Li ;
Wang, Feiyi ;
Shi, Ben ;
Li, Chunbao ;
Wang, Rui ;
Zhao, Chunchang .
DYES AND PIGMENTS, 2017, 136 :846-851
[7]   Mitochondria-Targeted Near-Infrared Fluorescent Off-On Probe for Selective Detection of Cysteine in Living Cells and in Vivo [J].
Han, Chunmiao ;
Yang, Huiran ;
Chen, Min ;
Su, Qianqian ;
Feng, Wei ;
Li, Fuyou .
ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (50) :27968-27975
[8]   A ratiometric fluorescent probe for detecting hypochlorite in the endoplasmic reticulum [J].
Hou, Ji-Ting ;
Kim, Hyeong Seok ;
Duan, Chong ;
Ji, Myung Sun ;
Wang, Shan ;
Zeng, Lintao ;
Ren, Wen Xiu ;
Kim, Jong Seung .
CHEMICAL COMMUNICATIONS, 2019, 55 (17) :2533-2536
[9]   Detection of hypochlorous acid fluctuation via a selective near-infrared fluorescent probe in living cells and in vivo under hypoxic stress [J].
Huang, Yan ;
He, Na ;
Wang, Yude ;
Zhang, Liangwei ;
Kang, Qi ;
Wang, Yunqing ;
Shen, Dazhong ;
Choo, Jaebum ;
Chen, Lingxin .
JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (15) :2557-2564
[10]   Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells [J].
Jiang, Yin ;
Zheng, Guansheng ;
Duan, Qinya ;
Yang, Liu ;
Zhang, Jie ;
Zhang, Huatang ;
He, Jun ;
Sun, Hongyan ;
Ho, Derek .
CHEMICAL COMMUNICATIONS, 2018, 54 (57) :7967-7970
1234