A convenient and expedient synthesis of 3-aryl-2H-azirine-2-carboxaldehydes

被引：5

作者：

Alajarín, M ^{[1
]}

Orenes, RA ^{[1
]}

Vidal, A ^{[1
]}

Pastor, A ^{[1
]}

机构：

[1] Univ Murcia, Dept Quim Organ, Fac Quim, E-30100 Murcia, Spain

来源：

SYNTHESIS-STUTTGART | 2003年 / 01期

关键词：

aldehydes; azides; heterocycles; oxidation; ring closure;

D O I：

10.1055/s-2003-36255

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new procedure for the synthesis of 3-aryl-2H-azirine-2-carboxaldehydes starting from cinnamyl alcohols is disclosed. This novel approach implies milder conditions and higher overall yields as compared to the previously reported methods. The key step, i.e. the formation of the azirine ring, involves the treatment of (Z)-3-aryl-3-azidoprop-2-en-1-ols with MnO2.

引用

页码：49 / 52

页数：4

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