Toward the Total Synthesis of Goniodomin A, An Actin-Targeting Marine Polyether Macrolide: Convergent Synthesis of the C15-C36 Segment

被引：26

作者：

Saito, Tomoyuki ^{[1
]}

Fuwa, Haruhiko ^{[1
]}

Sasaki, Makoto ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 22期

基金：

日本学术振兴会;

关键词：

Z-UNSATURATED ESTERS; IN-SITU GENERATION; ACTOMYOSIN ATPASE; ORGANIC-SYNTHESIS; TERMINAL ALKYNES; KETONES; FACILE; RING; CONFIGURATION; LANTHANOIDS;

D O I：

10.1021/ol902217q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective convergent synthesis of the C15-C36 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved. The present synthesis features palladium(0)-catalyzed, copper(I)-mediated Liebeskind-Srogl cross-coupling as the fragment assembly process.

引用

页码：5274 / 5277

页数：4

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