Factors associated with serum high mobility group box 1 (HMGB1) levels in a general population

被引：43

作者：

Fukami, Ako ^{[1
]}

Adachi, Hisashi ^{[1
]}

Yamagishi, Sho-ichi ^{[2
]}

Matsui, Takanori ^{[2
]}

Ueda, Shin-ichiro ^{[1
]}

Nakamura, Kazuo ^{[2
]}

Enomoto, Mika ^{[1
]}

Otsuka, Maki ^{[1
]}

Kumagae, Shun-ichi ^{[1
]}

Nanjo, Yasuki ^{[1
]}

Kumagai, Eita ^{[1
]}

Esaki, Eishi ^{[1
]}

Murayama, Kyoko ^{[1
]}

Hirai, Yuji ^{[1
]}

Imaizumi, Tsutomu ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Internal Med, Div Cardiovasc Med, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Fukuoka 8300011, Japan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2009年 / 58卷 / 12期

关键词：

GLYCATION END-PRODUCTS; SOLUBLE RECEPTOR; NEURITE OUTGROWTH; ENDOTHELIAL-CELLS; RAGE; SEPSIS; AMPHOTERIN; PROTEIN; ATHEROSCLEROSIS; DISEASE;

D O I：

10.1016/j.metabol.2009.05.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High mobility group box 1 (HMGB1), a nonhistone chromatin-associated protein, is implicated as a mediator of both infectious and noninfectious inflammatory conditions. Clinical research on this protein in humans just has begun; serum HMGB1 was reported to be elevated in a small number of critically ill patients suffering from sepsis. However, the kinetics, distribution and factors associated with circulating HMGB1 are unknown in a general population. In this study, we examined these issues in a large population of healthy subjects. Fasting blood samples were obtained from 626 subjects (237 males and 389 females). HMGB1 levels showed a skewed distribution with a mean of 1.65 +/- 0.04 ng/ml. Multiple stepwise regression analyses found that white blood cell (WBC) counts (P = .016) and the soluble form of receptor for advanced glycation end products (sRAGE; P < .001, inversely), which is also known to be a receptor for HMGB1, were independently associated with HMGB1 levels. We demonstrated for the first time that circulating HMGB1 levels were inversely associated with sRAGE levels in a general population. Because RAGE is involved in HMGB1 signaling, our present study suggests that sRAGE may capture and eliminate circulating HMGB1 in humans. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1688 / 1693

页数：6

共 31 条

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