Mechanism and management of cancer-associated thrombosis

被引：139

作者：

Mukai, Mikio ^{[1
]}

Oka, Toru ^{[1
]}

机构：

[1] Osaka Prefectural Hosp Org, Osaka Int Canc Inst, Dept Med Check Up, Oncocardiol Unit, Osaka, Japan

来源：

JOURNAL OF CARDIOLOGY | 2018年 / 72卷 / 1-2期

关键词：

Cancer; Venous thromboembolism; Atrial thromboembolism; Anti-angiogenic agents; Direct oral anticoagulants; VENOUS THROMBOEMBOLISM; TROUSSEAUS-SYNDROME; CHEMOTHERAPY; ENDOCARDITIS; PATHOGENESIS; DIAGNOSIS; ESC;

D O I：

10.1016/j.jjcc.2018.02.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thromboembolism is considered to have a substantial impact on outcomes in patients with cancer. Although progress in cancer therapy and the advent of new anticancer agents such as molecular targeted drugs have improved the outcomes of patients with cancer, the incidence of cancer-therapy-related thromboembolism is increasing, and the management of this adverse reaction has become a major problem. Cancer is intimately related to thrombosis. Thrombus formation results from the complex interaction of various factors, such as tissue factors, coagulation abnormalities, activated platelet activation, activated adhesion activation, and endothelial cell dysfunction. Thrombosis has an impact on cancer proliferation and extension. The condition known as "cancer-related thrombosis" must therefore be managed differently from thrombosis in patients without cancer. (C) 2018 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

引用

页码：89 / 93

页数：5

共 25 条

[11] Venous thromboembolism and prognosis in cancer [J].

Khorana, Alok A. .

THROMBOSIS RESEARCH, 2010, 125 (06) :490-493

[12] Venous Thromboembolism Prophylaxis and Treatment in Cancer: A Consensus Statement of Major Guidelines Panels and Call to Action [J].

Khorana, Alok A. ;

Streiff, Michael B. ;

Farge, Dominique ;

Mandala, Mario ;

Debourdeau, Philippe ;

Cajfinger, Francis ;

Marty, Michel ;

Falanga, Anna ;

Lyman, Gary H. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (29) :4919-4926

[13] 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) [J].

Konstantinides, Stavros V. ;

Torbicki, Adam ;

Agnelli, Giancarlo ;

Danchin, Nicolas ;

Fitzmaurice, David ;

Galie, Nazzareno ;

Gibbs, J. Simon R. ;

Huisman, Menno V. ;

Humbert, Marc ;

Kucher, Nils ;

Lang, Irene ;

Lankeit, Mareike ;

Lekakis, John ;

Maack, Christoph ;

Mayer, Eckhard ;

Meneveau, Nicolas ;

Perrier, Arnaud ;

Pruszczyk, Piotr ;

Rasmussen, Lars H. ;

Schindler, Thomas H. ;

Svitil, Pavel ;

Noordegraaf, Anton Vonk ;

Zamorano, Jose Luis ;

Zompatori, Maurizio .

EUROPEAN HEART JOURNAL, 2014, 35 (43) :3033-3080

[14] NONBACTERIAL THROMBOTIC ENDOCARDITIS AS A CAUSE OF CEREBRAL AND MYOCARDIAL-INFARCTION [J].

KURAMOTO, K ;

MATSUSHITA, S ;

YAMANOUCHI, H .

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1984, 48 (09) :1000-1006

[15] Cardiovascular Toxic Effects of Targeted Cancer Therapies [J].

Moslehi, Javid J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (15) :1457-1467

[16] Risk of Arterial Thromboembolism in Patients With Cancer [J].

Navi, Babak B. ;

Reiner, Anne S. ;

Kamel, Hooman ;

Iadecola, Costantino ;

Okin, Peter M. ;

Elkind, Mitchell S. V. ;

Panageas, Katherine S. ;

DeAngelis, Lisa M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 70 (08) :927-938

[17] Trousseau's syndrome -: what is the evidence?: A population-based autopsy study [J].

Ögren, M ;

Bergqvist, D ;

Wählander, K ;

Eriksson, H ;

Sternby, NH .

THROMBOSIS AND HAEMOSTASIS, 2006, 95 (03) :541-545

[18] Oncogenes, Trousseau syndrome, and cancer-related changes in the coagulome of mice and humans [J].

Rak, Janusz ;

Yu, Joanne L. ;

Luyendyk, James ;

Mackman, Nigel .

CANCER RESEARCH, 2006, 66 (22) :10643-10646

[19] Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism [J].

Raskob, Gary E. ;

van Es, Nick ;

Verhamme, Peter ;

Carrier, Marc ;

Di Nisio, Marcello ;

Garcia, David ;

Grosso, Michael A. ;

Kakkar, Ajay K. ;

Kovacs, Michael J. ;

Mercuri, Michele F. ;

Meyer, Guy ;

Segers, Annelise ;

Shi, Minggao ;

Wang, Tzu-Fei ;

Yeo, Erik ;

Zhang, George ;

Zwicker, Jeffrey I. ;

Weitz, Jeffrey I. ;

Buller, Harry R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (07) :615-624

[20] TROUSSEAUS SYNDROME AND OTHER MANIFESTATIONS OF CHRONIC DISSEMINATED COAGULOPATHY IN PATIENTS WITH NEOPLASMS - CLINICAL, PATHOPHYSIOLOGIC, AND THERAPEUTIC FEATURES [J].

SACK, GH ;

LEVIN, J ;

BELL, WR .

MEDICINE, 1977, 56 (01) :1-37

← 1 2 3 →