Easy synthesis of highly fluorescent carbon dots from albumin and their photoluminescent mechanism and biological imaging applications

被引：90
作者：
Hu, Xiaohua [1 ]
An, Xueqin [1 ]
Li, Lielie [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 58卷
关键词：
Carbon dots; Novel synthesis method; Photoluminescent mechanism; Biological imaging; GRAPHENE QUANTUM DOTS; GREEN SYNTHESIS; HYDROLYSIS; NANODOTS; BLUE;
D O I：
10.1016/j.msec.2015.09.066
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A simple and green approach was developed to synthesize highly fluorescent carbon dots (CDs) using albumin as a carbon source in aqueous solution at room temperature. The CDs were characterized by excellent monodispersion, superior photostability, pH-independent emission, long fluorescence lifetime and high quantum yield (QY). The photoluminescent (PL) mechanism of CDs was explored by means of time-resolved PL decay, and the results revealed that PL originated from the emission of both defect state and intrinsic state. In addition, biological imaging with the application of CDs was carried out in human breast cancer Bcap-37 cell, which demonstrated that CDs were provided with an excellent biocompatiblity, low cytotoxicity and good transmembrane ability. Besides, CDs could be considered as a potential substitute for organic dyes or semiconductor quantum dots (SQDs) in biological imaging. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：730 / 736
页数：7
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