Bullfight without killers: interferon rules pathology in HLH

被引：3

作者：

Schneider, EM ^{[1
]}

机构：

[1] Univ Clin Ulm, Ulm, Germany

来源：

BLOOD | 2004年 / 104卷 / 03期

关键词：

D O I：

10.1182/blood-2004-05-1973

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Jordan and colleagues present a perform deficiency-dependent model for virus-induced HLH in mice, highlighting IFN-gamma as the only cytokine relevant for major clinical characteristics and mortality in mice.

引用

页码：600 / 601

页数：2

共 6 条

[1] FAMILIAL HAEMOPHAGOCYTIC RETICULOSIS [J].

FARQUHAR, JW ;

CLAIREAUX, AE .

ARCHIVES OF DISEASE IN CHILDHOOD, 1952, 27 (136) :519-525

[2] Munc13-4 is essential for cytolytic granule fusion [J].

Feldmann, J ;

Le Deist, F ;

Fischer, A ;

Basile, GDS .

M S-MEDECINE SCIENCES, 2004, 20 (02) :144-146

[3] Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis [J].

Osugi, Y ;

Hara, J ;

Tagawa, S ;

Takai, K ;

Hosoi, G ;

Matsuda, Y ;

Ohta, H ;

Fujisaki, H ;

Kobayashi, M ;

Sakata, N ;

KawaHa, K ;

Okada, S ;

Tawa, A .

BLOOD, 1997, 89 (11) :4100-4103

[4] Inducible Hsp70 expression analysis after heat and physical exercise - Transcriptional, protein expression, and subcellular localization [J].

Schneider, EM ;

Niess, AM ;

Lorenz, I ;

Northoff, H ;

Fehrenbach, E .

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS, 2002, 973 :8-12

[5] Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cell-induced apoptosis [J].

Schneider, EM ;

Lorenz, I ;

Müller-Rosenberger, M ;

Steinbach, G ;

Kron, M ;

Janka-Schaub, GE .

BLOOD, 2002, 100 (08) :2891-2898

[6]

Stepp SE, 1999, SCIENCE, V286, P1957, DOI 10.1126/science.286.5446.1957

← 1 →