Dickkopf-3: Current Knowledge in Kidney Diseases

被引：29

作者：

Fang, Xiangdong ^{[1
]}

Hu, Jing ^{[2
]}

Chen, Yanxia ^{[1
]}

Shen, Wen ^{[3
]}

Ke, Ben ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Nephrol, Nanchang, Jiangxi, Peoples R China

[2] Third Hosp Nanchang, Nanchang, Jiangxi, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

Dickkopf-related protein 3; wnt signaling pathway; chronic kidney disease; idiopathic membranous nephropathy; biomarker; DKK3; CANDIDATE; PATHWAY;

D O I：

10.3389/fphys.2020.533344

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression and assessing the effects of interventions. We review the biological role of DKK3 as an agonist in chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD) and as an antagonist in idiopathic membranous nephropathy (IMN). In addition, we present the clinical applications of DKK3 in acute kidney disease and tubulointerstitial fibrosis, suggesting that urine DKK3 may be a potential biomarker for acute kidney disease and CKD. Further research into the mechanism of DKK3 and its use as a diagnostic tool, alone or in combination with other biomarkers, could prove clinically useful for better understanding the pathology of kidney diseases and improving early detection and treatment.

引用

页数：7

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