Recombination in HIV: An important viral evolutionary strategy

被引：121
作者：
Burke, DS
机构：
[1] Walter Reed Army Inst. of Research, Rockville, MD
[2] Walter Reed Army Inst. of Research, Rockville, MD 20850
来源：
EMERGING INFECTIOUS DISEASES | 1997年 / 3卷 / 03期
关键词：
D O I：
10.3201/eid0303.970301
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete RNA genomic strands. Homologous recombination can occur when a cell is coinfected with two different but related strains. Naturally occurring recombinant HIV strains have been found in infected patients in regions of the world where multiple genotypic variants cocirculate. One recombinant HIV strain has spread rapidly to millions of persons in Southeast Asia. Recombination is a mechanism whereby high level and multidrug-resistant strains may be generated in individual treated patients. Recombination also poses theoretical problems for the development of a safe HIV vaccine. Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy.
引用
收藏
页码：253 / 259
页数：7
相关论文
共 40 条
  • [1] DUAL INFECTION WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 OF DISTINCT ENVELOPE SUBTYPES IN HUMANS
    ARTENSTEIN, AW
    VANCOTT, TC
    MASCOLA, JR
    CARR, JK
    HEGERICH, PA
    GAYWEE, J
    SANDERSBUELL, E
    ROBB, ML
    DAYHOFF, DE
    THITIVICHIANLERT, S
    NITAYAPHAN, S
    MCNEIL, JG
    BIRX, DL
    MICHAEL, RA
    BURKE, DS
    MCCUTCHAN, FE
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (04) : 805 - 810
  • [2] Burke D S, 1995, AIDS, V9 Suppl A, pS171
  • [3] BURKE DS, 1997, AIDS BIOL DIAGNOSIS
  • [4] Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication
    Caliendo, AM
    Savara, A
    An, D
    DeVore, K
    Kaplan, JC
    DAquila, RT
    [J]. JOURNAL OF VIROLOGY, 1996, 70 (04) : 2146 - 2153
  • [5] Genetic characterization of new west African simian immunodeficiency virus SIVsm: Geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop
    Chen, ZW
    Telfer, P
    Gettie, A
    Reed, P
    Zhang, LQ
    Ho, DD
    Marx, PA
    [J]. JOURNAL OF VIROLOGY, 1996, 70 (06) : 3617 - 3627
  • [6] COFFIN JM, 1992, CURR TOP MICROBIOL, V176, P143
  • [7] DUAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION AND RECOMBINATION IN A DUALLY EXPOSED TRANSFUSION RECIPIENT
    DIAZ, RS
    SABINO, EC
    MAYER, A
    MOSLEY, JW
    BUSCH, MP
    [J]. JOURNAL OF VIROLOGY, 1995, 69 (06) : 3273 - 3281
  • [8] FELSENSTEIN J, 1976, GENETICS, V83, P845
  • [9] Broader tropism and higher cytopathicity for CD4(+) T cells of a syncytium-inducing compared to a non-syncytium-inducing HIV-1 isolate as a mechanism for accelerated CD4(+) T cell decline in vivo
    Fouchier, RAM
    Meyaard, L
    Brouwer, M
    Hovenkamp, E
    Schuitemaker, H
    [J]. VIROLOGY, 1996, 219 (01) : 87 - 95
  • [10] SUPERINFECTION OF A CHIMPANZEE WITH A 2ND STRAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS
    FULTZ, PN
    SRINIVASAN, A
    GREENE, CR
    BUTLER, D
    SWENSON, RB
    MCCLURE, HM
    [J]. JOURNAL OF VIROLOGY, 1987, 61 (12) : 4026 - 4029
1234