USE OF RESOVIST IN MAGNETIC PARTICLE IMAGING

Magnetic particle imaging (MPI) is a novel tomographic imaging technique visualizing colloidal magnetic material. Experimental data of several research groups indicate that Resovist, a clinically approved MRI contrast agent consisting of superparamagnetic iron oxide (SPIO) nanoparticles, is superior to a number of other experimental as well as clinically approved SPIO in its performance as MN tracer. Nevertheless, the dose of Resovist needed to achieve a good spatial and temporal resolution in simulation studies and initial animal experiments is rather high. Therefore, novel tracer materials are needed in order to foster further improvement of this new imaging modality. This contribution summarizes data for Resovist in MPI and ideas for tracer optimization.