Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor

被引：2

作者：

Yamamoto, K

Yoshikawa, R

Okuyama, S

Takahashi, Y

Karasawa, Y

Hino, N

Miyoshi, T

Araki, H

Hanabusa, K

Shirai, H

Tomisawa, K

机构：

[1] TAISHO PHARMACEUT CO LTD,MED RES LABS,LAB 1,OMIYA,SAITAMA 330,JAPAN

[2] TAISHO PHARMACEUT CO LTD,PHARMACEUT RES LABS,PHARMACOL LAB,OMIYA,SAITAMA 330,JAPAN

[3] TAISHO PHARMACEUT CO LTD,RES STRATEGY & PLANNING SECT,OMIYA,SAITAMA 330,JAPAN

[4] SHINSHU UNIV,FAC TEXT SCI & TECHNOL,DEPT FUNCT POLYMER SCI,UEDA,NAGANO 386,JAPAN

来源：

LIFE SCIENCES | 1996年 / 59卷 / 25-26期

关键词：

growth factor; neurotrophic factor; astroglial cells; cerebral ischemia; Mongolian gerbil; neuronal degeneration;

D O I：

10.1016/S0024-3205(96)00570-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.

引用

页码：2139 / 2146

页数：8

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