Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor

被引:2
|
作者
Yamamoto, K
Yoshikawa, R
Okuyama, S
Takahashi, Y
Karasawa, Y
Hino, N
Miyoshi, T
Araki, H
Hanabusa, K
Shirai, H
Tomisawa, K
机构
[1] TAISHO PHARMACEUT CO LTD,MED RES LABS,LAB 1,OMIYA,SAITAMA 330,JAPAN
[2] TAISHO PHARMACEUT CO LTD,PHARMACEUT RES LABS,PHARMACOL LAB,OMIYA,SAITAMA 330,JAPAN
[3] TAISHO PHARMACEUT CO LTD,RES STRATEGY & PLANNING SECT,OMIYA,SAITAMA 330,JAPAN
[4] SHINSHU UNIV,FAC TEXT SCI & TECHNOL,DEPT FUNCT POLYMER SCI,UEDA,NAGANO 386,JAPAN
关键词
growth factor; neurotrophic factor; astroglial cells; cerebral ischemia; Mongolian gerbil; neuronal degeneration;
D O I
10.1016/S0024-3205(96)00570-X
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.
引用
收藏
页码:2139 / 2146
页数:8
相关论文
共 50 条
  • [21] Aqua[4′-(4-chlorophenyl)-2,2′:6′,2"-terpyridine]nitratocopper(II) nitrate [4′-(4-chlorophenyl)-2,2′:6′,2"-terpyridine]dinitratocopper(II) monohydrate
    Zhao, Juan
    Shi, Shuo
    Yao, Tianming
    Tan, Zhongfei
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : M346 - U626
  • [22] 2-(4-Methylphenyl)acetohydrazide
    Praveen, A. S.
    Jasinski, Jerry P.
    Krauss, Shannon T.
    Yathirajan, H. S.
    Narayana, B.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3467 - +
  • [23] Chiral 2,2':6',2''-terpyridine ligands for metallosupramolecular chemistry .2. Metal complexes of 4'-([(1S)-endo]-bornyloxy)-2,2':6',2''-terpyridine, 4'-([(1R)-endo]-bornyloxy)-2,2':6',2''-terpyridine, 4'-quniinyl-2,2':6',2''-terpyridine, and 4'-(2,2':6',2''-terpyridinyl)-(1S)-10-camphorsulfonate
    Constable, EC
    Kulke, T
    Neuburger, M
    Zehnder, M
    NEW JOURNAL OF CHEMISTRY, 1997, 21 (10) : 1091 - 1102
  • [24] 4′-(4-fluorophenyl)-2,2′:6′,2"-terpyridine -: an aryl-2,2′:6′,2"-terpyridine with an electron-releasing aryl substituent
    Constable, EC
    Neuburger, M
    Smith, DR
    Zehnder, M
    INORGANICA CHIMICA ACTA, 1998, 276 (1-2) : 359 - 365
  • [25] 5,5''-bis{4-[bis(4-methylphenyl)amino]phenyl}-2,2':5',2''-terthiophene and 5,5'''-bis{4-[bis(4-methylphenyl)amino]phenyl}-2,2':5',2'':5'',2'''-quaterthiophene as a novel family of amorphous molecular materials
    Noda, T
    Imae, I
    Noma, N
    Shirota, Y
    ADVANCED MATERIALS, 1997, 9 (03) : 239 - +
  • [26] Synthesis and luminescence properties of platinum(II) complexes of 4′-chloro-2,2′:6′,2"-terpyridine and 4,4′,4"-trichloro-2,2′:6′,2"-terpyridine
    Hobert, SE
    Carney, JT
    Cummings, SD
    INORGANICA CHIMICA ACTA, 2001, 318 (1-2) : 89 - 96
  • [27] Cyclic Voltammetric Investigations of Newly Synthesized Cd(II) 4′-(4-methylphenyl)-2,2′:6′,2"-Terpyridyl Complex in DMF solution
    Ershad, Sohrab
    Saghatrfroush, Lotfali
    Khodmarz, Jafar
    Telfer, Shane G.
    INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2011, 6 (09): : 3997 - 4005
  • [28] SYNTHESIS OF 4'-VINYL-2,2'-6',2''-TERPYRIDINE
    POTTS, KT
    KONWAR, D
    JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (15): : 4815 - 4816
  • [29] 4′-[2-(Trifluoromethyl)phenyl]-2,2′:6′,2"-terpyridine
    Ledwaba, Peter
    Munro, Orde Q.
    Stewart, Kirsty
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O376 - U2645
  • [30] 4,4"-Dichloro-4′-(2-thienyl)-2,2′:6′,2"-terpyridine
    Husson, Jerome
    Guyard, Laurent
    MOLBANK, 2019, 2019 (03)