Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor

被引：2
|
作者：
Yamamoto, K
Yoshikawa, R
Okuyama, S
Takahashi, Y
Karasawa, Y
Hino, N
Miyoshi, T
Araki, H
Hanabusa, K
Shirai, H
Tomisawa, K
机构：
[1] TAISHO PHARMACEUT CO LTD,MED RES LABS,LAB 1,OMIYA,SAITAMA 330,JAPAN
[2] TAISHO PHARMACEUT CO LTD,PHARMACEUT RES LABS,PHARMACOL LAB,OMIYA,SAITAMA 330,JAPAN
[3] TAISHO PHARMACEUT CO LTD,RES STRATEGY & PLANNING SECT,OMIYA,SAITAMA 330,JAPAN
[4] SHINSHU UNIV,FAC TEXT SCI & TECHNOL,DEPT FUNCT POLYMER SCI,UEDA,NAGANO 386,JAPAN
来源：
LIFE SCIENCES | 1996年 / 59卷 / 25-26期
关键词：
growth factor; neurotrophic factor; astroglial cells; cerebral ischemia; Mongolian gerbil; neuronal degeneration;
D O I：
10.1016/S0024-3205(96)00570-X
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.
引用
收藏
页码：2139 / 2146
页数：8
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