Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines

被引：33

作者：

Abed, Hassen Bel ^{[1
]}

Mammoliti, Oscar ^{[2
]}

Bande, Omprakash ^{[1
]}

Van Lommen, Guy ^{[2
]}

Herdewijn, Piet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Leuven, Belgium

[2] Galapagos NV, Med Chem Lab, B-2800 Mechelen, Belgium

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 36期

关键词：

DIELS-ALDER REACTIONS; CONVENIENT STRATEGY; APPEL; DERIVATIVES;

D O I：

10.1039/c4ob01201a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The elaboration of the first organophosphorus-catalyzed diaza-Wittig reaction is reported. This catalytic reaction is applied to the synthesis of substituted pyridazine and phthalazine derivatives bearing electron-withdrawing groups with good to excellent yields from substrates containing a diazo functionality as the starting material and a phospholene oxide as the catalyst.

引用

页码：7159 / 7166

页数：8

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