The Association of CARD8 rs2043211 Polymorphism with Preeclampsia in the Chinese Han Population

被引：5

作者：

Wang, Xuefeng ^{[1
]}

Liu, Mengchun ^{[2
]}

Liu, Zhen ^{[3
]}

Niu, Zhaoyuan ^{[4
]}

Liu, Shiguo ^{[1
,5
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Prenatal Diag Ctr, Qingdao 266071, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao 266071, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Qingdao Key Lab Hypertens, Qingdao 266071, Peoples R China

[4] Qingdao Univ, Affiliated Hosp, Gynecol, Qingdao 266071, Peoples R China

[5] Qingdao Univ, Affiliated Hosp, Genet Lab, Qingdao 266071, Peoples R China

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2015年 / 80卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Preeclampsia; CARD8; Polymorphism; NECROSIS-FACTOR-ALPHA; KAPPA-B PATHWAY; RHEUMATOID-ARTHRITIS; P.C10X POLYMORPHISM; HELLP-SYNDROME; GENES; PREGNANCY; APOPTOSIS; CELLS; SUSCEPTIBILITY;

D O I：

10.1159/000377630

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The purpose of our study was to investigate the association between polymorphism of rs2043211 in CARD8 and susceptibility to preeclampsia (PE) in the Chinese Han population. Methods: 261 PE patients and 451 controls were genotyped for rs2043211 with the method of TaqMan allele discrimination assays. Clinical data were collected to perform genotype-phenotype analysis. Results: Our study suggested that the rs2043211 variant was associated with the development of PE in the Chinese Han population. The genotypic and allelic frequencies differed significantly between the two groups (chi(2) = 8.198, p = 0.017 by genotype; chi(2) = 6.741, p = 0.009 by allele). The T allele was the risk allele for predisposition to PE (OR = 1.331, 95% Cl 1.072-1.652). Conclusion: The polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of PE in the Chinese Han population. (C) 2015 S. Karger AG, Basel

引用

页码：193 / 198

页数：6

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