Mollanol A, a Diterpenoid with a New C-Nor-D-homograyanane Skeleton from the Fruits of Rhododendron molle

被引：42

作者：

Li, Yong ^{[1
,2
]}

Liu, Yun-Bao ^{[1
,2
]}

Liu, Yang-Lan ^{[1
,2
]}

Wang, Chen ^{[1
,2
]}

Wu, Lian-Qiu ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Ma, Shuang-Gang ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 16期

基金：

中国国家自然科学基金;

关键词：

ROOTS;

D O I：

10.1021/ol5020653

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new grayanoids, mollanol A (1) and rhodomollein XXV (2), were isolated from the fruits of Rhododendron molle. Their structures were elucidated by spectroscopic methods and X-ray diffraction analyses. Mollanol A (1) possesses a new C-nor-D-homograyanane carbon skeleton, while rhodomollein XXV (2) is the first example of an 11,16-epoxygrayanane and features a caged oxatricyclo[3.3.1.0(3.7)]nonane ring system. Plausible biogenetic pathways for 1 were proposed. Compound 1 exhibited transcriptional activation effects on the xbp1 upstream promoter in IEC-6, 293T, and RAW264.7 cells.

引用

页码：4320 / 4323

页数：4

共 19 条

[1] Studies directed to the synthesis of the unusual cardiotoxic agent kalmanol. Enantioselective construction of the advanced tetracyclic 7-oxy-5,6-dideoxy congener [J].