The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

被引：186

作者：

Benson, Eleni ^{[1
]}

Li, Ryan ^{[1
]}

Eisele, David ^{[1
]}

Fakhry, Carole ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA

[2] Milton J Dance Jr Head & Neck Canc Ctr, Baltimore, MD 21204 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

来源：

ORAL ONCOLOGY | 2014年 / 50卷 / 06期

关键词：

Head and neck cancer; Oropharyngeal neoplasms; HPV; Risk factors; Prognosis; HUMAN-PAPILLOMAVIRUS INFECTION; TRANSORAL ROBOTIC SURGERY; RISK HUMAN-PAPILLOMAVIRUS; OROPHARYNGEAL CANCER; PROGNOSTIC-SIGNIFICANCE; UNITED-STATES; P16(INK4A) EXPRESSION; IMPROVED SURVIVAL; TONSILLAR CANCER; SEXUAL-BEHAVIORS;

D O I：

10.1016/j.oraloncology.2013.09.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most commonly arise from the oropharynx and are responsible for the increasing incidence of oropharyngeal SCC (OSCC) in the United States (US) and abroad. HPV-positive OSCC (HPV-OSCC) has a unique demographic and risk factor profile and tumor biology. HPV-OSCC patients tend to be white, younger, and have a higher cumulative exposure to sexual behaviors as compared with HPV-negative OSCC patients. HPV-positive tumor status also significantly improves survival, and is indeed the single strongest prognostic factor for OSCC. The mechanisms that underlie the improved prognosis conferred by HPV-positive disease are unknown. The purpose of this review is to describe the clinical impact of HPV status in HNSCC, particularly in OSCC, both in terms of the unique clinic-demographic profile and prognostic implications. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：565 / 574

页数：10

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