Synthesis and antibacterial activity of 1-beta-methylcarbapenem having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety

被引：3
作者：
Nam, KH
Oh, CH
Cho, JK
Kim, HJ
Lee, KS
Cho, JH
机构：
[1] HANYANG UNIV, DEPT CHEM, SEOUL 133791, SOUTH KOREA
[2] DONG KOOK PHARMACEUT CO, SEOUL 135280, SOUTH KOREA
[3] KYUNGWON UNIV, DEPT CHEM, SUNGNAM 461701, SOUTH KOREA
来源：
ARCHIV DER PHARMAZIE | 1996年 / 329卷 / 10期
关键词：
1-beta-methylcarbapenems; antibacterial activity; MIC; substituent effect;
D O I：
10.1002/ardp.19963291004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of new series of 1-beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram negative bacteria are reported and the effect of the substituent on the bicyclic ring was investigated and was in agreement with findings from our previous studies.
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页码：443 / 446
页数：4
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