Enzymatic synthesis of 5-amino quinoline oligomers and evaluation of their free radical scavenging activity

被引:4
作者
Bilici, Ali [1 ]
Gecibesler, Ibrahim Halil [2 ]
Kaya, Ismet [1 ]
机构
[1] Canakkale Onsekiz Mart Univ, Fac Sci & Arts, Dept Chem, Polymer Synth & Anal Lab, TR-17020 Canakkale, Turkey
[2] Bingol Univ, Fac Hlth Sci, Lab Nat Prod Res, TR-12000 Bingol, Turkey
关键词
enzymatic polymerization; HRP; 5-aminoquinoline; antioxidant activity; DPPH; CONDUCTING POLYMERS; OXIDATIVE POLYMERIZATION; FACILE SYNTHESIS; PHENYLENEDIAMINE; COPOLYMER;
D O I
10.1139/cjc-2016-0210
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The compound 5-aminoquinoline (AQ) was treated with horseradish peroxidase (HRP) and H2O2 in a reaction medium containing a dioxane: phosphate buffer mixture (70:30). Products (OAQ) with a degree of polymerization ranging from 4 to 12 were obtained. H-1 NMR, FTIR, UV-vis, SEM, TG-DTA, DSC, XRD analysis, and conductivity measurements were conducted for characterization of OAQ. Compared with a monomer, OAQ showed higher thermal stability. After heating to 1000 degrees C, 46% of the initial weight of the OAQ remained. The antioxidant efficiencies of the monomer and oligomer were evaluated by the typical spectrophotometric method such as the bleaching of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. OAQ showed improved DPPH activity compared with the AQ monomer.
引用
收藏
页码:7 / 15
页数:9
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