Semisynthesis of a functional K+ channel

被引：46

作者：

Valiyaveetil, FI

Sekedat, M

Muir, TW

MacKinnon, R

机构：

[1] Rockefeller Univ, Lab Synth Prot Chem, New York, NY 10021 USA

[2] Rockefeller Univ, Lab Mol Neurobiol & Biophys, New York, NY 10021 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期

关键词：

ion channels; peptides; potassium; protein engineering;

D O I：

10.1002/anie.200453849

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Selective ion-conduction properties in lipid membranes have been found for a semisynthetic KcsA K+ channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K+ channel with chemical modification of the main-chain atoms of the selectivity filter. The picture shows the single-channel responses of the semisynthetic K+ channel and its structure.

引用

页码：2504 / 2507

页数：4