Mutations Alter RNA-Mediated Conversion of Human Prions

被引：6

作者：

Alred, Erik J. ^{[1
]}

Lodangco, Izra ^{[1
]}

Gallaher, Jennifer ^{[1
]}

Hansmann, Ulrich H. E. ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem, 101 Stephenson Pkwy, Norman, OK 73019 USA

来源：

ACS OMEGA | 2018年 / 3卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; PARTICLE MESH EWALD; PROTEIN-STRUCTURE; OLIGOMERIZATION; DISEASES; DOMAIN; WATER; PRPC;

D O I：

10.1021/acsomega.7b02007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Prion diseases are connected with self-replication and self-propagation of misfolded proteins. The rate-limiting factor is the formation of the initial seed. We have recently studied the early stages in the conversion between functional PrPC and the infectious scrapie PrPSC form, triggered by the binding of RNA. Here, we study how this process is modulated by the prion sequence. We focus on residues 129 and 178, which are connected to the hereditary neurodegenerative disease fatal familial insomnia.

引用

页码：3936 / 3944

页数：9

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