No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression

被引：32

作者：

Jessen, Frank ^{[1
]}

Schuhmacher, Anna ^{[1
]}

von Widdern, Ole ^{[1
]}

Guttenthaler, Vera ^{[1
]}

Hofels, Susanne ^{[1
]}

Suliman, Husam ^{[1
]}

Scheef, Lukas ^{[2
]}

Block, Wolfgang ^{[2
]}

Urbach, Horst ^{[2
]}

Maier, Wolfgang ^{[1
]}

Zobel, Astrid ^{[1
]}

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

[2] Univ Bonn, Dept Radiol, D-53105 Bonn, Germany

来源：

PSYCHIATRIC GENETICS | 2009年 / 19卷 / 02期

关键词：

brain-derived neurotrophic factor; hippocampus; major depression; GENE POLYMORPHISM; HUMAN-MEMORY; BDNF; SCHIZOPHRENIA; MORPHOLOGY; VARIANTS; DISORDER;

D O I：

10.1097/YPG.0b013e32832080ce

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recently, an association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in patients with major depression has been reported. Here,,Ne aimed at replicating this finding in an independent German sample. We included 79 patients with unipolar major depressive episodes and 84 healthy comparison participants. The brain-derived neurotrophic factor Val66Met polymorphism was determined in all participants. The volume of the hippocampus was manually traced on high-resolution magnetic resonance images. The hippocampal volumes of patients were significantly smaller than those of the comparison participants, confirming previous reports. There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants. Psychiatr Genet 19:99-101 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

收藏

页码：99 / 101

页数：3

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