Reference Values and Determinants of Fractional Concentration of Exhaled Nitric Oxide in Healthy Children

被引：18

作者：

Cho, Hyun-Ju ^{[1
]}

Jung, Young-Ho ^{[2
,3
]}

Yang, Song-I ^{[1
,3
]}

Lee, Eun ^{[1
,3
]}

Kim, Hyung Young ^{[3
,4
]}

Seo, Ju-Hee ^{[3
,5
]}

Kwon, Ji-Won ^{[3
,6
]}

Kim, Byoung-Ju ^{[3
,7
]}

Kim, Hyo-Bin ^{[3
,8
]}

Lee, So-Yeon ^{[3
,9
]}

Song, Dae Jin ^{[3
,10
]}

Kim, Woo Kyung ^{[3
,11
]}

Jang, Gwang Cheon ^{[3
,12
]}

Shim, Jung Yeon ^{[3
,13
]}

Hong, Soo-Jong ^{[1
,3
]}

机构：

[1] Univ Ulsan, Childhood Asthma Atopy Ctr, Asan Med Ctr, Dept Pediat,Coll Med, Seoul 138736, South Korea

[2] CHA Univ, Sch Med, Dept Pediat, Songnam, South Korea

[3] Univ Ulsan, Asan Med Ctr, Res Ctr Standardizat Allerg Dis, Coll Med, Seoul 138736, South Korea

[4] Kosin Univ, Coll Med, Gospel Hosp, Dept Pediat, Pusan, South Korea

[5] Korea Canc Ctr Hosp, Dept Pediat, Seoul, South Korea

[6] Seoul Natl Univ, Coll Med, Dept Pediat, Bundang Hosp, Seoul, South Korea

[7] Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Pediat, Pusan, South Korea

[8] Inje Univ, Coll Med, Sanggye Paik Hosp, Dept Pediat, Seoul, South Korea

[9] Hallym Univ, Coll Med, Hallym Sacred Heart Hosp, Dept Pediat, Anyang, South Korea

[10] Korea Univ, Coll Med, Dept Pediat, Guro Hosp, Seoul 136705, South Korea

[11] Inje Univ, Coll Med, Dept Pediat, Seoul Paik Hosp, Seoul, South Korea

[12] Natl Hlth Insurance Corp, Ilsan Hosp, Dept Pediat, Seoul, South Korea

[13] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2014年 / 6卷 / 02期

关键词：

FeNO; reference value; determinants; healthy; children; ALLERGIC RHINITIS; AGE; ASTHMA; PREVALENCE; HEIGHT; GENDER; RISK;

D O I：

10.4168/aair.2014.6.2.169

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose: Measurement of the fractional concentration of exhaled nitric oxide (FeNO) is a quantitative, noninvasive, simple, safe method of assessing airway inflammation. While FeNO measurement has been standardized, reference values for elementary school children are scarce. The aim of this study was to establish reference values for FeNO in children. Methods: FeNO was measured in elementary school children at 6-12 years of age in Seoul, Korea, following American Thoracic Society guidelines and using a chemiluminescence analyzer (NIOX Exhaled Nitric Oxide Monitoring System, Aerocrine, Sweden). A total of 1,252 children completed a modified International Study of Asthma and Allergy in Children (ISAAC) questionnaire; FeNO was measured in 1,063 children according to the protocol and in 808 children defined as healthy controls. Results: Mean FeNO were 10.32 ppb, 16.58 ppb, and 12.36 ppb in non-atopic, atopic, and all 808 healthy controls, respectively. FeNO was not associated with age and gender. The FeNO reference equations were determined by multiple linear regression analysis, taking into account the variables of age, height, weight, total IgE, eosinophil percent, and bronchial hyper-responsiveness (methacholine PC20). FeNO=0.776+0.003 X total IgE+0.340 X eosinophil percent; coefficient of determination (62)=0.084 in the 501 healthy non-atopic controls. FeNO=-18.365+1.536 X eosinophil percent, R-2=0.183 in the 307 healthy atopic controls; and FeNO=-7.888+0.130 X Height+0.004 X total IgE+1.233 X eosinophil percent, R-2=0.209 in the 808 all healthy controls. Eosinophil percent was correlated with FeNO in all healthy controls. FeNO was not associated with BMI. Conclusion: This study provides reference values for FeNO that can be used to evaluate airway inflammation in elementary school children. Determinants that could most accurately predict FeNO in healthy school-age children were assessed.

引用

页码：169 / 174

页数：6

共 22 条

[1] ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 [J].