Efficient Synthesis of New Tetracyclic Benzofuro[3,2-d]imidazo[1,2-a]pyrimidine-2,5-(1H,3H)-diones

被引：3

作者：

Hu Yanggen ^{[1
,2
,3
]}

Liu Min ^{[1
]}

Ding Mingwu ^{[1
]}

机构：

[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China

[2] Yunyang Med Coll, Taihe Hosp, Dept Pharm, Shiyan 442000, Hubei, Peoples R China

[3] Yunyang Med Coll, Inst Med Chem, Shiyan 442000, Hubei, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 02期

基金：

中国国家自然科学基金;

关键词：

benzofuro[3,2-d]imidazo[1,2-a]pyrimidine-2,5-(1H,3H)-dione; iminophosphorane; aza-Wittig reaction; isocyanate; carbodiimide; WITTIG/HETEROCUMULENE-MEDIATED ANNULATION; FUNGICIDAL ACTIVITIES; IMIDAZOLE ALKALOIDS; BIOLOGICAL-ACTIVITY; DERIVATIVES;

D O I：

10.1002/cjoc.201090072

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aza-Wittig reaction of iminophosphorane (1) with aromaic isocyanates gave carbodiimides (2), which were allowed to react further with a-amino ester in the presence of a catalytic amount of sodium ethoxide to give selectively new tetracyclic benzofuro [3,2-d]imidazo[1,2-a]pyrimidine-2,5-(1H,3H)-diones (5) in good yields. X-ray structure analysis of 5i verified the proposed structure and the reaction selectivity.

引用

页码：309 / 312

页数：4