Poly(α,L-glutamic acid) Microspheres for Oral Insulin Delivery

被引：0

作者：

Han Ya-Dong ^{[1
,2
]}

Xia Jia-Liang ^{[1
,2
]}

He Pan ^{[1
,2
]}

Tian Hua-Yu ^{[1
]}

Chen Xue-Si ^{[1
]}

Jing Xia-Bin ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2009年 / 30卷 / 12期

关键词：

Poly(alpha; L-glutamic acid); Microsphere; Oral insulin delivery; Anhydrous emulsion; pH-sensitive drug release; RELEASE; BIOAVAILABILITY; NANOPARTICLES; COMPLEXATION; COPOLYMER; HYDROGELS; CALCIUM;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Insulin-loaded poly(alpha,L-glutamic acid) microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5-20 mu m, and drug loading of 5%-9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated.

引用

页码：2521 / 2524

页数：4

共 19 条

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