Poly(α,L-glutamic acid) Microspheres for Oral Insulin Delivery

被引：0
|
作者：
Han Ya-Dong [1 ,2 ]
Xia Jia-Liang [1 ,2 ]
He Pan [1 ,2 ]
Tian Hua-Yu [1 ]
Chen Xue-Si [1 ]
Jing Xia-Bin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2009年 / 30卷 / 12期
关键词：
Poly(alpha; L-glutamic acid); Microsphere; Oral insulin delivery; Anhydrous emulsion; pH-sensitive drug release; RELEASE; BIOAVAILABILITY; NANOPARTICLES; COMPLEXATION; COPOLYMER; HYDROGELS; CALCIUM;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Insulin-loaded poly(alpha,L-glutamic acid) microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5-20 mu m, and drug loading of 5%-9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated.
引用
收藏
页码：2521 / 2524
页数：4
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