Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype

被引：20

作者：

Pellegrino, Sara ^{[2
]}

Ferri, Nicola ^{[1
]}

Colombo, Noemi ^{[3
]}

Cremona, Edoardo ^{[1
]}

Corsini, Alberto ^{[1
]}

Fanelli, Roberto ^{[2
,3
]}

Gelmi, Maria Luisa ^{[2
]}

Cabrele, Chiara ^{[3
,4
]}

机构：

[1] Univ Milan, Dipartimento Sci Farmacol, I-20133 Milan, Italy

[2] Univ Milan, DISMAB, Sez Chim Organ, I-20133 Milan, Italy

[3] Univ Regensburg, Fak Chem & Pharmazie, D-93053 Regensburg, Germany

[4] Ruhr Univ Bochum, Fak Chem & Biochem, D-44801 Bochum, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 22期

关键词：

Id proteins; Protein domain recognition; Helix-loop-helix; Peptide dimerization; Peptide mimic; Solid-phase peptide synthesis; Smooth muscle cell; LOOP-HELIX DOMAIN; DNA-BINDING; IN-VIVO; HOMODIMERIZATION; ATHEROSCLEROSIS; DIFFERENTIATION; EXPRESSION; FRAGMENTS; CANCER; E47;

D O I：

10.1016/j.bmcl.2009.09.105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6298 / 6302

页数：5

共 32 条

[31] A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions [J].